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- NCIT_C28845 IAO_0000115 "A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity. Aztreonam preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3), which is involved in bacterial cell wall synthesis, thereby inhibiting bacterial cell wall integrity and leading to cell lysis and death. This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms." @default.
- NCIT_C28845 NCIT_NHC0 "C28845" @default.
- NCIT_C28845 NCIT_P106 "Antibiotic" @default.
- NCIT_C28845 NCIT_P106 "Organic Chemical" @default.
- NCIT_C28845 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C28845 NCIT_P107 "Aztreonam" @default.
- NCIT_C28845 NCIT_P108 "Aztreonam" @default.
- NCIT_C28845 NCIT_P175 "646279" @default.
- NCIT_C28845 NCIT_P207 "C0699281" @default.
- NCIT_C28845 NCIT_P210 "78110-38-0" @default.
- NCIT_C28845 NCIT_P319 "G2B4VE5GH8" @default.
- NCIT_C28845 NCIT_P322 "CTRP" @default.
- NCIT_C28845 NCIT_P322 "FDA" @default.
- NCIT_C28845 NCIT_P329 "788184" @default.
- NCIT_C28845 NCIT_P330 "788184" @default.
- NCIT_C28845 NCIT_P350 "C13H17N5O8S2" @default.
- NCIT_C28845 NCIT_P366 "Aztreonam" @default.
- NCIT_C28845 NCIT_P368 "CHEBI:161680" @default.
- NCIT_C28845 NCIT_P399 "788184" @default.
- NCIT_C28845 normalizedInformationContent "100" @default.
- NCIT_C28845 referenceCount "1" @default.
- NCIT_C28845 hasExactSynonym "AZTREONAM" @default.
- NCIT_C28845 hasExactSynonym "Azactam" @default.
- NCIT_C28845 hasExactSynonym "Aztreonam" @default.
- NCIT_C28845 hasExactSynonym "SQ 26,776" @default.
- NCIT_C28845 inSubset NCIT_C116977 @default.
- NCIT_C28845 inSubset NCIT_C116978 @default.
- NCIT_C28845 inSubset NCIT_C176424 @default.
- NCIT_C28845 inSubset NCIT_C63923 @default.
- NCIT_C28845 type Class @default.
- NCIT_C28845 isDefinedBy ncit.owl @default.
- NCIT_C28845 label "Aztreonam" @default.
- NCIT_C28845 subClassOf NCIT_C1908 @default.
- NCIT_C28845 subClassOf NCIT_C1909 @default.
- NCIT_C28845 subClassOf NCIT_C254 @default.
- NCIT_C28845 subClassOf NCIT_C258 @default.
- NCIT_C28845 subClassOf NCIT_C260 @default.
- NCIT_C28845 subClassOf NCIT_C28845 @default.