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- NCIT_C28903 IAO_0000115 "A synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity. After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 (AT1) in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure." @default.
- NCIT_C28903 NCIT_NHC0 "C28903" @default.
- NCIT_C28903 NCIT_P106 "Organic Chemical" @default.
- NCIT_C28903 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C28903 NCIT_P108 "Candesartan Cilexetil" @default.
- NCIT_C28903 NCIT_P207 "C0527379" @default.
- NCIT_C28903 NCIT_P210 "145040-37-5" @default.
- NCIT_C28903 NCIT_P319 "R85M2X0D68" @default.
- NCIT_C28903 NCIT_P322 "FDA" @default.
- NCIT_C28903 NCIT_P329 "546971" @default.
- NCIT_C28903 NCIT_P330 "546971" @default.
- NCIT_C28903 NCIT_P350 "C33H34N6O6" @default.
- NCIT_C28903 NCIT_P366 "Candesartan_Cilexetil" @default.
- NCIT_C28903 NCIT_P399 "546971" @default.
- NCIT_C28903 normalizedInformationContent "100" @default.
- NCIT_C28903 referenceCount "1" @default.
- NCIT_C28903 hasExactSynonym "Atacand" @default.
- NCIT_C28903 hasExactSynonym "Blopress" @default.
- NCIT_C28903 hasExactSynonym "CANDESARTAN CILEXETIL" @default.
- NCIT_C28903 hasExactSynonym "Candesartan Cilexetil" @default.
- NCIT_C28903 inSubset NCIT_C173381 @default.
- NCIT_C28903 inSubset NCIT_C173383 @default.
- NCIT_C28903 inSubset NCIT_C176424 @default.
- NCIT_C28903 inSubset NCIT_C63923 @default.
- NCIT_C28903 type Class @default.
- NCIT_C28903 isDefinedBy ncit.owl @default.
- NCIT_C28903 label "Candesartan Cilexetil" @default.
- NCIT_C28903 subClassOf NCIT_C1908 @default.
- NCIT_C28903 subClassOf NCIT_C1909 @default.
- NCIT_C28903 subClassOf NCIT_C270 @default.
- NCIT_C28903 subClassOf NCIT_C28903 @default.
- NCIT_C28903 subClassOf NCIT_C66930 @default.
- NCIT_C28903 subClassOf NCIT_C78274 @default.