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- NCIT_C28958 IAO_0000115 "The hydrochloride salt of a diacetyl derivative of the opiate morphine, a naturally occurring alkaloid extracted from the seedpod of the Asian poppy (Papaver sp.). Once administered, diamorphine (or diacetylmorphine) is rapidly hydrolyzed to 6-monoacetylmorphine (6-MAM) and then to the end-product morphine which binds to opiate receptors located throughout the mammalian nervous and gastrointestinal systems. Inducing a potent analgesia, the use of diamoprhine is often escalated due to a tolerance effect, resulting in abuse that is associated with fatal overdose, abortion, venous sclerosis, and opportunistic infections, among other adverse effects. (NCI04)" @default.
- NCIT_C28958 NCIT_A6 NCIT_C424 @default.
- NCIT_C28958 NCIT_NHC0 "C28958" @default.
- NCIT_C28958 NCIT_P106 "Organic Chemical" @default.
- NCIT_C28958 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C28958 NCIT_P108 "Diacetylmorphine Hydrochloride" @default.
- NCIT_C28958 NCIT_P175 "302357" @default.
- NCIT_C28958 NCIT_P207 "C0282128" @default.
- NCIT_C28958 NCIT_P210 "1502-95-0" @default.
- NCIT_C28958 NCIT_P319 "8H672SHT8E" @default.
- NCIT_C28958 NCIT_P322 "FDA" @default.
- NCIT_C28958 NCIT_P329 "40567" @default.
- NCIT_C28958 NCIT_P330 "40567" @default.
- NCIT_C28958 NCIT_P350 "C21H23NO5.HCl" @default.
- NCIT_C28958 NCIT_P366 "Diamorphine_Hydrochloride" @default.
- NCIT_C28958 NCIT_P399 "40567" @default.
- NCIT_C28958 normalizedInformationContent "100" @default.
- NCIT_C28958 referenceCount "1" @default.
- NCIT_C28958 hasExactSynonym "DIAMORPHINE HYDROCHLORIDE ANHYDROUS" @default.
- NCIT_C28958 hasExactSynonym "Diacetylmorphine Hydrochloride" @default.
- NCIT_C28958 hasExactSynonym "Diamorphine Hydrochloride" @default.
- NCIT_C28958 hasExactSynonym "Heroin Hydrochloride" @default.
- NCIT_C28958 hasExactSynonym "Heroine Hydrochloride" @default.
- NCIT_C28958 hasExactSynonym "Morphinan-3,6alpha-diol, 7,8-didehydro-4,5alpha-epoxy-17-methyl-, Morphine, Diacetate (ester), Hydrochloride" @default.
- NCIT_C28958 inSubset NCIT_C176424 @default.
- NCIT_C28958 inSubset NCIT_C63923 @default.
- NCIT_C28958 type Class @default.
- NCIT_C28958 isDefinedBy ncit.owl @default.
- NCIT_C28958 label "Diacetylmorphine Hydrochloride" @default.
- NCIT_C28958 subClassOf NCIT_C1506 @default.
- NCIT_C28958 subClassOf NCIT_C1908 @default.
- NCIT_C28958 subClassOf NCIT_C1909 @default.
- NCIT_C28958 subClassOf NCIT_C1913 @default.
- NCIT_C28958 subClassOf NCIT_C1916 @default.
- NCIT_C28958 subClassOf NCIT_C221 @default.
- NCIT_C28958 subClassOf NCIT_C28958 @default.
- NCIT_C28958 subClassOf NCIT_C67413 @default.
- NCIT_C28958 subClassOf NCIT_C718 @default.
- NCIT_C28958 subClassOf NCIT_C78272 @default.