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- NCIT_C28985 IAO_0000115 "A nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. As a nonsteroidal anti-inflammatory drug (NSAID), diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins. This agent also may inhibit COX-2-mediated tumor angiogenesis. When inhibiting COX-2, diclofenac may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. This agent may be more active against COX-2 than several other carboxylic acid-containing NSAIDs. (NCI04)" @default.
- NCIT_C28985 NCIT_A5 NCIT_C47983 @default.
- NCIT_C28985 NCIT_A5 NCIT_C47984 @default.
- NCIT_C28985 NCIT_NHC0 "C28985" @default.
- NCIT_C28985 NCIT_P106 "Organic Chemical" @default.
- NCIT_C28985 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C28985 NCIT_P108 "Diclofenac" @default.
- NCIT_C28985 NCIT_P207 "C0012091" @default.
- NCIT_C28985 NCIT_P210 "15307-86-5" @default.
- NCIT_C28985 NCIT_P319 "144O8QL0L1" @default.
- NCIT_C28985 NCIT_P322 "FDA" @default.
- NCIT_C28985 NCIT_P325 "The active ingredient in a drug that is used to treat the symptoms of rheumatoid arthritis and is being studied in the prevention and treatment of some types of skin cancer. It blocks substances that cause inflammation and pain. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of cyclooxygenase inhibitor, a type of nonsteroidal anti-inflammatory drug (NSAID), and a type of antiangiogenesis agent." @default.
- NCIT_C28985 NCIT_P350 "C14H11Cl2NO2" @default.
- NCIT_C28985 NCIT_P366 "Diclofenac" @default.
- NCIT_C28985 NCIT_P368 "CHEBI:47381" @default.
- NCIT_C28985 NCIT_R122 NCIT_C16484 @default.
- NCIT_C28985 NCIT_R122 NCIT_C16486 @default.
- NCIT_C28985 NCIT_R122 NCIT_C16554 @default.
- NCIT_C28985 NCIT_R122 NCIT_C16865 @default.
- NCIT_C28985 NCIT_R122 NCIT_C16946 @default.
- NCIT_C28985 NCIT_R122 NCIT_C17021 @default.
- NCIT_C28985 NCIT_R122 NCIT_C20027 @default.
- NCIT_C28985 NCIT_R122 NCIT_C26548 @default.
- NCIT_C28985 NCIT_R122 NCIT_C28459 @default.
- NCIT_C28985 NCIT_R122 NCIT_C28750 @default.
- NCIT_C28985 normalizedInformationContent "100" @default.
- NCIT_C28985 referenceCount "1" @default.
- NCIT_C28985 hasExactSynonym "2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid" @default.
- NCIT_C28985 hasExactSynonym "DICLOFENAC" @default.
- NCIT_C28985 hasExactSynonym "Diclofenac" @default.
- NCIT_C28985 hasExactSynonym "diclofenac" @default.
- NCIT_C28985 inSubset NCIT_C63923 @default.
- NCIT_C28985 type Class @default.
- NCIT_C28985 isDefinedBy ncit.owl @default.
- NCIT_C28985 label "Diclofenac" @default.
- NCIT_C28985 subClassOf B373d16d6f5bbf830e50ba9f15050addb @default.
- NCIT_C28985 subClassOf Bb3bac14667cab76f37f821f8562dcb2e @default.
- NCIT_C28985 subClassOf NCIT_C1323 @default.
- NCIT_C28985 subClassOf NCIT_C1908 @default.
- NCIT_C28985 subClassOf NCIT_C1909 @default.
- NCIT_C28985 subClassOf NCIT_C2198 @default.
- NCIT_C28985 subClassOf NCIT_C2356 @default.
- NCIT_C28985 subClassOf NCIT_C241 @default.
- NCIT_C28985 subClassOf NCIT_C257 @default.
- NCIT_C28985 subClassOf NCIT_C28985 @default.
- NCIT_C28985 subClassOf NCIT_C471 @default.
- NCIT_C28985 subClassOf NCIT_C78272 @default.