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- NCIT_C29006 IAO_0000115 "A dibenzoxepin derivative and tricyclic antidepressant with antipruritic and sedative activities. Doxepin blocks the reuptake of norepinephrine and serotonin into presynaptic terminals thereby prolonging the availability of the monoaminergic neurotransmitters within the synaptic cleft and enhancing their action leading to sedative effects. Doxepin also has antagonistic effects on histamine (H1 and H2), 5-HT2, alpha-1 adrenergic, and muscarinic receptors. The antipruritic effect of this agent is the result mediated through inhibition of histamine receptors." @default.
- NCIT_C29006 NCIT_A6 NCIT_C65475 @default.
- NCIT_C29006 NCIT_NHC0 "C29006" @default.
- NCIT_C29006 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29006 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29006 NCIT_P107 "Doxepin Hydrochloride" @default.
- NCIT_C29006 NCIT_P108 "Doxepin Hydrochloride" @default.
- NCIT_C29006 NCIT_P175 "108160" @default.
- NCIT_C29006 NCIT_P207 "C0700535" @default.
- NCIT_C29006 NCIT_P210 "1229-29-4" @default.
- NCIT_C29006 NCIT_P319 "3U9A0FE9N5" @default.
- NCIT_C29006 NCIT_P322 "CTRP" @default.
- NCIT_C29006 NCIT_P322 "FDA" @default.
- NCIT_C29006 NCIT_P329 "681082" @default.
- NCIT_C29006 NCIT_P330 "681082" @default.
- NCIT_C29006 NCIT_P366 "Doxepin_Hydrochloride" @default.
- NCIT_C29006 NCIT_P399 "681082" @default.
- NCIT_C29006 NCIT_R122 NCIT_C16484 @default.
- NCIT_C29006 NCIT_R122 NCIT_C16486 @default.
- NCIT_C29006 NCIT_R122 NCIT_C16554 @default.
- NCIT_C29006 NCIT_R122 NCIT_C16865 @default.
- NCIT_C29006 NCIT_R122 NCIT_C16946 @default.
- NCIT_C29006 NCIT_R122 NCIT_C17021 @default.
- NCIT_C29006 NCIT_R122 NCIT_C17287 @default.
- NCIT_C29006 NCIT_R122 NCIT_C20027 @default.
- NCIT_C29006 NCIT_R122 NCIT_C26548 @default.
- NCIT_C29006 NCIT_R122 NCIT_C28459 @default.
- NCIT_C29006 normalizedInformationContent "100" @default.
- NCIT_C29006 referenceCount "1" @default.
- NCIT_C29006 hasExactSynonym "Adapin" @default.
- NCIT_C29006 hasExactSynonym "DOXEPIN HYDROCHLORIDE" @default.
- NCIT_C29006 hasExactSynonym "Doxepin Hydrochloride" @default.
- NCIT_C29006 hasExactSynonym "Sinequan" @default.
- NCIT_C29006 inSubset NCIT_C116977 @default.
- NCIT_C29006 inSubset NCIT_C116978 @default.
- NCIT_C29006 inSubset NCIT_C176424 @default.
- NCIT_C29006 inSubset NCIT_C63923 @default.
- NCIT_C29006 type Class @default.
- NCIT_C29006 isDefinedBy ncit.owl @default.
- NCIT_C29006 label "Doxepin Hydrochloride" @default.
- NCIT_C29006 subClassOf B2b87930c54281c158ce91baf3453bc75 @default.
- NCIT_C29006 subClassOf B8077edfaa328e295dd500b242365921d @default.
- NCIT_C29006 subClassOf NCIT_C1908 @default.
- NCIT_C29006 subClassOf NCIT_C1909 @default.
- NCIT_C29006 subClassOf NCIT_C265 @default.
- NCIT_C29006 subClassOf NCIT_C29006 @default.
- NCIT_C29006 subClassOf NCIT_C78272 @default.
- NCIT_C29006 subClassOf NCIT_C94727 @default.