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- NCIT_C29035 IAO_0000115 "An oral contraceptive formulation containing the semisynthetic estrogen, ethinyl estradiol, combined with the synthetic progestin, norethindrone, with estrogenic and progestogenic activities, respectively. Ethinyl estradiol binds to and activates intracellular estrogen receptors found in the reproductive tract and other estrogen-responsive tissues. The activated complex enters the nucleus, binds to the estrogen response elements on DNA, activates the transcription of genes involved in the maintenance of the female reproductive system, inhibits the release of follicle stimulating hormone (FSH) from the anterior pituitary, and suppresses the development of the ovarian follicle. Norethindrone binds to intracellular progesterone receptors in progesterone-responsive tissues, such as the pituitary and those found in the reproductive system, and the activated ligand/receptor complex interacts with specific progesterone response elements on DNA, which results in the alteration in protein synthesis, the inhibition of ovulation, an increase in cervical mucus production, the induction of the secretory phase of the endometrial cycle, and the inhibition of luteinizing hormone (LH) release. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system and alters the structure of the endometrium to discourage implantation." @default.
- NCIT_C29035 NCIT_A7 NCIT_C17075 @default.
- NCIT_C29035 NCIT_A7 NCIT_C38361 @default.
- NCIT_C29035 NCIT_NHC0 "C29035" @default.
- NCIT_C29035 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29035 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29035 NCIT_P107 "Ethinyl Estradiol/Norethindrone" @default.
- NCIT_C29035 NCIT_P108 "Ethinyl Estradiol/Norethindrone" @default.
- NCIT_C29035 NCIT_P207 "C1260235" @default.
- NCIT_C29035 NCIT_P322 "CTRP" @default.
- NCIT_C29035 NCIT_P329 "759182" @default.
- NCIT_C29035 NCIT_P330 "759182" @default.
- NCIT_C29035 NCIT_P366 "Ethinyl_Estradiol-Norethindrone" @default.
- NCIT_C29035 NCIT_P399 "759182" @default.
- NCIT_C29035 normalizedInformationContent "100" @default.
- NCIT_C29035 referenceCount "1" @default.
- NCIT_C29035 hasExactSynonym "Aranelle" @default.
- NCIT_C29035 hasExactSynonym "Balziva" @default.
- NCIT_C29035 hasExactSynonym "Brevicon" @default.
- NCIT_C29035 hasExactSynonym "Ethinyl Estradiol/Norethindrone" @default.
- NCIT_C29035 hasExactSynonym "Gencept" @default.
- NCIT_C29035 hasExactSynonym "Modicon" @default.
- NCIT_C29035 hasExactSynonym "Norcept-E" @default.
- NCIT_C29035 hasExactSynonym "Norethin" @default.
- NCIT_C29035 hasExactSynonym "Norinyl" @default.
- NCIT_C29035 hasExactSynonym "Nortrel" @default.
- NCIT_C29035 hasExactSynonym "Ortho-Novum 1/35" @default.
- NCIT_C29035 hasExactSynonym "Ortho-Novum" @default.
- NCIT_C29035 hasExactSynonym "Ovcon" @default.
- NCIT_C29035 inSubset NCIT_C116977 @default.
- NCIT_C29035 inSubset NCIT_C116978 @default.
- NCIT_C29035 inSubset NCIT_C176424 @default.
- NCIT_C29035 type Class @default.
- NCIT_C29035 isDefinedBy ncit.owl @default.
- NCIT_C29035 label "Ethinyl Estradiol/Norethindrone" @default.
- NCIT_C29035 subClassOf NCIT_C1908 @default.
- NCIT_C29035 subClassOf NCIT_C1909 @default.
- NCIT_C29035 subClassOf NCIT_C29035 @default.
- NCIT_C29035 subClassOf NCIT_C29629 @default.
- NCIT_C29035 subClassOf NCIT_C29640 @default.