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- NCIT_C29047 IAO_0000115 "A synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity. Fenofibrate is hydrolyzed in vivo to its active metabolite fenofibric acid that binds to and activates peroxisome proliferator activated receptor alpha (PPARalpha), resulting in the activation of lipoprotein lipase and reduction of the production of apoprotein C-III, an inhibitor of lipoprotein lipase activity. Increased lipolysis and a fall in plasma triglycerides, in turn, leads to the modification of the small, dense low density lipoporotein (LDL) particles into larger particles that are catabolized more rapidly due to a greater affinity for cholesterol receptors. In addition, activation of PPARalpha also increases the synthesis of apoproteins A-I, A-II, and high density lipoprotein (HDL)-cholesterol. Overall, fenofibrate reduces total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) while increasing HDL cholesterol." @default.
- NCIT_C29047 NCIT_NHC0 "C29047" @default.
- NCIT_C29047 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29047 NCIT_P107 "Fenofibrate" @default.
- NCIT_C29047 NCIT_P108 "Fenofibrate" @default.
- NCIT_C29047 NCIT_P207 "C0033228" @default.
- NCIT_C29047 NCIT_P210 "49562-28-9" @default.
- NCIT_C29047 NCIT_P319 "U202363UOS" @default.
- NCIT_C29047 NCIT_P322 "CTRP" @default.
- NCIT_C29047 NCIT_P322 "FDA" @default.
- NCIT_C29047 NCIT_P325 "A drug used to treat high levels of cholesterol and triglycerides in the blood. Fenofibrate is being studied in the treatment of advanced cancers in young patients and in the treatment of other conditions. It is a type of antilipidemic agent." @default.
- NCIT_C29047 NCIT_P329 "459750" @default.
- NCIT_C29047 NCIT_P330 "459750" @default.
- NCIT_C29047 NCIT_P350 "C20H21ClO4" @default.
- NCIT_C29047 NCIT_P366 "Fenofibrate" @default.
- NCIT_C29047 NCIT_P368 "CHEBI:5001" @default.
- NCIT_C29047 NCIT_P399 "459750" @default.
- NCIT_C29047 normalizedInformationContent "100" @default.
- NCIT_C29047 referenceCount "1" @default.
- NCIT_C29047 hasExactSynonym "FENOFIBRATE" @default.
- NCIT_C29047 hasExactSynonym "Fenofibrate" @default.
- NCIT_C29047 hasExactSynonym "Lofibra" @default.
- NCIT_C29047 hasExactSynonym "TriCor" @default.
- NCIT_C29047 hasExactSynonym "Tricor" @default.
- NCIT_C29047 hasExactSynonym "fenofibrate" @default.
- NCIT_C29047 inSubset NCIT_C116977 @default.
- NCIT_C29047 inSubset NCIT_C116978 @default.
- NCIT_C29047 inSubset NCIT_C173381 @default.
- NCIT_C29047 inSubset NCIT_C173383 @default.
- NCIT_C29047 inSubset NCIT_C176424 @default.
- NCIT_C29047 inSubset NCIT_C63923 @default.
- NCIT_C29047 type Class @default.
- NCIT_C29047 isDefinedBy ncit.owl @default.
- NCIT_C29047 label "Fenofibrate" @default.
- NCIT_C29047 subClassOf NCIT_C1908 @default.
- NCIT_C29047 subClassOf NCIT_C1909 @default.
- NCIT_C29047 subClassOf NCIT_C29047 @default.
- NCIT_C29047 subClassOf NCIT_C29703 @default.
- NCIT_C29047 subClassOf NCIT_C78276 @default.
- NCIT_C29047 subClassOf NCIT_C98150 @default.