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- NCIT_C29055 IAO_0000115 "The acetonide salt form of fluocinolone, a synthetic fluorinated corticosteroid with antiinflammatory, antipruritic and vasoconstrictive properties. Fluocinolone is a glucocorticoid receptor agonist that binds to cytoplasmic glucocorticoid receptors and subsequently translocates to the nucleus where it initiates the transcription of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both are potent mediators of inflammation. Fluocinolone exerts its vasoconstrictive effect through inhibition of nitric oxide synthase, thereby blocking nitric oxide production and effectively diminishing the effect of nitric oxide on vascular smooth muscles leading to reduced blood flow." @default.
- NCIT_C29055 NCIT_NHC0 "C29055" @default.
- NCIT_C29055 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29055 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29055 NCIT_P108 "Fluocinolone Acetonide" @default.
- NCIT_C29055 NCIT_P175 "92339" @default.
- NCIT_C29055 NCIT_P207 "C0016298" @default.
- NCIT_C29055 NCIT_P210 "67-73-2" @default.
- NCIT_C29055 NCIT_P319 "0CD5FD6S2M" @default.
- NCIT_C29055 NCIT_P322 "FDA" @default.
- NCIT_C29055 NCIT_P350 "C24H30F2O6" @default.
- NCIT_C29055 NCIT_P366 "Fluocinolone_Acetonide" @default.
- NCIT_C29055 NCIT_R122 NCIT_C16484 @default.
- NCIT_C29055 NCIT_R122 NCIT_C16486 @default.
- NCIT_C29055 NCIT_R122 NCIT_C16554 @default.
- NCIT_C29055 NCIT_R122 NCIT_C16865 @default.
- NCIT_C29055 NCIT_R122 NCIT_C16946 @default.
- NCIT_C29055 NCIT_R122 NCIT_C17021 @default.
- NCIT_C29055 NCIT_R122 NCIT_C17573 @default.
- NCIT_C29055 NCIT_R122 NCIT_C20027 @default.
- NCIT_C29055 NCIT_R122 NCIT_C26548 @default.
- NCIT_C29055 NCIT_R122 NCIT_C28459 @default.
- NCIT_C29055 normalizedInformationContent "100" @default.
- NCIT_C29055 referenceCount "1" @default.
- NCIT_C29055 hasExactSynonym "(6alpha,11beta,16alpha)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione" @default.
- NCIT_C29055 hasExactSynonym "FLUOCINOLONE ACETONIDE" @default.
- NCIT_C29055 hasExactSynonym "Fluocinolone Acetonide" @default.
- NCIT_C29055 inSubset NCIT_C63923 @default.
- NCIT_C29055 type Class @default.
- NCIT_C29055 isDefinedBy ncit.owl @default.
- NCIT_C29055 label "Fluocinolone Acetonide" @default.
- NCIT_C29055 subClassOf NCIT_C147908 @default.
- NCIT_C29055 subClassOf NCIT_C1636 @default.
- NCIT_C29055 subClassOf NCIT_C1908 @default.
- NCIT_C29055 subClassOf NCIT_C1909 @default.
- NCIT_C29055 subClassOf NCIT_C211 @default.
- NCIT_C29055 subClassOf NCIT_C2364 @default.
- NCIT_C29055 subClassOf NCIT_C29055 @default.
- NCIT_C29055 subClassOf NCIT_C308 @default.
- NCIT_C29055 subClassOf NCIT_C521 @default.
- NCIT_C29055 subClassOf NCIT_C548 @default.
- NCIT_C29055 subClassOf NCIT_C574 @default.