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- NCIT_C29056 IAO_0000115 "A synthetic glucocorticoid and derivative of fluocinolone acetonide with anti-inflammatory and antipruritic activities. Fluocinonide binds the glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements. Lipocortin-1 is one factor induced by fluocinonide that interacts and inhibits cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins. In addition, MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade resulting in pro-inflammatory effects via Jun N-terminal kinase and c-Jun. Finally, fluocinonide binds to and inhibits nuclear factor kappa-B directly, resulting in inhibition of cyclooxygenase 2 transcription and subsequent prostaglandin synthesis." @default.
- NCIT_C29056 NCIT_NHC0 "C29056" @default.
- NCIT_C29056 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29056 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29056 NCIT_P108 "Fluocinonide" @default.
- NCIT_C29056 NCIT_P175 "101791" @default.
- NCIT_C29056 NCIT_P207 "C0016299" @default.
- NCIT_C29056 NCIT_P210 "356-12-7" @default.
- NCIT_C29056 NCIT_P302 "plaque-type psoriasis" @default.
- NCIT_C29056 NCIT_P319 "2W4A77YPAN" @default.
- NCIT_C29056 NCIT_P322 "FDA" @default.
- NCIT_C29056 NCIT_P350 "C26H32F2O7" @default.
- NCIT_C29056 NCIT_P366 "Fluocinonide" @default.
- NCIT_C29056 NCIT_R122 NCIT_C16484 @default.
- NCIT_C29056 NCIT_R122 NCIT_C16486 @default.
- NCIT_C29056 NCIT_R122 NCIT_C16554 @default.
- NCIT_C29056 NCIT_R122 NCIT_C16865 @default.
- NCIT_C29056 NCIT_R122 NCIT_C16946 @default.
- NCIT_C29056 NCIT_R122 NCIT_C17021 @default.
- NCIT_C29056 NCIT_R122 NCIT_C17573 @default.
- NCIT_C29056 NCIT_R122 NCIT_C20027 @default.
- NCIT_C29056 NCIT_R122 NCIT_C26548 @default.
- NCIT_C29056 NCIT_R122 NCIT_C28459 @default.
- NCIT_C29056 normalizedInformationContent "100" @default.
- NCIT_C29056 referenceCount "1" @default.
- NCIT_C29056 hasExactSynonym "(6alpha,11beta,16alpha)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione" @default.
- NCIT_C29056 hasExactSynonym "FLUOCINONIDE" @default.
- NCIT_C29056 hasExactSynonym "Fluocinonide" @default.
- NCIT_C29056 hasExactSynonym "Lidex" @default.
- NCIT_C29056 hasExactSynonym "Vanos" @default.
- NCIT_C29056 inSubset NCIT_C63923 @default.
- NCIT_C29056 type Class @default.
- NCIT_C29056 isDefinedBy ncit.owl @default.
- NCIT_C29056 label "Fluocinonide" @default.
- NCIT_C29056 subClassOf NCIT_C147908 @default.
- NCIT_C29056 subClassOf NCIT_C1636 @default.
- NCIT_C29056 subClassOf NCIT_C1908 @default.
- NCIT_C29056 subClassOf NCIT_C1909 @default.
- NCIT_C29056 subClassOf NCIT_C211 @default.
- NCIT_C29056 subClassOf NCIT_C2364 @default.
- NCIT_C29056 subClassOf NCIT_C29056 @default.
- NCIT_C29056 subClassOf NCIT_C308 @default.
- NCIT_C29056 subClassOf NCIT_C521 @default.
- NCIT_C29056 subClassOf NCIT_C548 @default.
- NCIT_C29056 subClassOf NCIT_C574 @default.