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- NCIT_C29061 IAO_0000115 "The propionate salt form of fluticasone, a synthetic trifluorinated glucocorticoid receptor agonist with antiallergic, antiinflammatory and antipruritic effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2, which triggers cascade of reactions involved in synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production." @default.
- NCIT_C29061 NCIT_A7 NCIT_C17071 @default.
- NCIT_C29061 NCIT_NHC0 "C29061" @default.
- NCIT_C29061 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29061 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29061 NCIT_P107 "Fluticasone Propionate" @default.
- NCIT_C29061 NCIT_P108 "Fluticasone Propionate" @default.
- NCIT_C29061 NCIT_P207 "C0117996" @default.
- NCIT_C29061 NCIT_P210 "80474-14-2" @default.
- NCIT_C29061 NCIT_P319 "O2GMZ0LF5W" @default.
- NCIT_C29061 NCIT_P322 "CTRP" @default.
- NCIT_C29061 NCIT_P322 "FDA" @default.
- NCIT_C29061 NCIT_P329 "682628" @default.
- NCIT_C29061 NCIT_P330 "682628" @default.
- NCIT_C29061 NCIT_P350 "C25H31F3O5S" @default.
- NCIT_C29061 NCIT_P366 "Fluticasone_Propionate" @default.
- NCIT_C29061 NCIT_P368 "CHEBI:31441" @default.
- NCIT_C29061 NCIT_P399 "682628" @default.
- NCIT_C29061 NCIT_R122 NCIT_C16484 @default.
- NCIT_C29061 NCIT_R122 NCIT_C16486 @default.
- NCIT_C29061 NCIT_R122 NCIT_C16554 @default.
- NCIT_C29061 NCIT_R122 NCIT_C16865 @default.
- NCIT_C29061 NCIT_R122 NCIT_C16946 @default.
- NCIT_C29061 NCIT_R122 NCIT_C17021 @default.
- NCIT_C29061 NCIT_R122 NCIT_C17573 @default.
- NCIT_C29061 NCIT_R122 NCIT_C20027 @default.
- NCIT_C29061 NCIT_R122 NCIT_C26548 @default.
- NCIT_C29061 NCIT_R122 NCIT_C28459 @default.
- NCIT_C29061 normalizedInformationContent "100" @default.
- NCIT_C29061 referenceCount "1" @default.
- NCIT_C29061 hasExactSynonym "(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic Acid, S-(Fluoromethyl) Ester" @default.
- NCIT_C29061 hasExactSynonym "FLUTICASONE PROPIONATE" @default.
- NCIT_C29061 hasExactSynonym "Flonase" @default.
- NCIT_C29061 hasExactSynonym "Flovent" @default.
- NCIT_C29061 hasExactSynonym "Fluticasone Propionate" @default.
- NCIT_C29061 inSubset NCIT_C116977 @default.
- NCIT_C29061 inSubset NCIT_C116978 @default.
- NCIT_C29061 inSubset NCIT_C176424 @default.
- NCIT_C29061 inSubset NCIT_C63923 @default.
- NCIT_C29061 type Class @default.
- NCIT_C29061 isDefinedBy ncit.owl @default.
- NCIT_C29061 label "Fluticasone Propionate" @default.
- NCIT_C29061 subClassOf NCIT_C147908 @default.
- NCIT_C29061 subClassOf NCIT_C1636 @default.
- NCIT_C29061 subClassOf NCIT_C1908 @default.
- NCIT_C29061 subClassOf NCIT_C1909 @default.
- NCIT_C29061 subClassOf NCIT_C211 @default.
- NCIT_C29061 subClassOf NCIT_C2364 @default.
- NCIT_C29061 subClassOf NCIT_C29061 @default.
- NCIT_C29061 subClassOf NCIT_C308 @default.
- NCIT_C29061 subClassOf NCIT_C521 @default.
- NCIT_C29061 subClassOf NCIT_C548 @default.
- NCIT_C29061 subClassOf NCIT_C574 @default.