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- NCIT_C29062 IAO_0000115 "The sodium salt of a synthetic lipid-lowering agent with potential antineoplastic activity. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. Through the inhibition of mevalonate synthesis, statins, like fluvastatin, have been shown to inhibit the production of dolichol, geranylpyrophosphate (GPP) and farnesylpyrophosphate (FPP) and the isoprenylation of the intracellular G-proteins Ras and Rho, which may result in antiangiogenic, apoptotic, and antimetastatic effects in susceptible tumor cell populations." @default.
- NCIT_C29062 NCIT_A32 NCIT_C1909 @default.
- NCIT_C29062 NCIT_A6 NCIT_C61768 @default.
- NCIT_C29062 NCIT_A7 NCIT_C54701 @default.
- NCIT_C29062 NCIT_NHC0 "C29062" @default.
- NCIT_C29062 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29062 NCIT_P107 "Fluvastatin Sodium" @default.
- NCIT_C29062 NCIT_P108 "Fluvastatin Sodium" @default.
- NCIT_C29062 NCIT_P207 "C0246203" @default.
- NCIT_C29062 NCIT_P210 "93957-55-2" @default.
- NCIT_C29062 NCIT_P319 "PYF7O1FV7F" @default.
- NCIT_C29062 NCIT_P322 "CTRP" @default.
- NCIT_C29062 NCIT_P322 "FDA" @default.
- NCIT_C29062 NCIT_P322 "GDC" @default.
- NCIT_C29062 NCIT_P329 "487588" @default.
- NCIT_C29062 NCIT_P330 "487588" @default.
- NCIT_C29062 NCIT_P350 "C24H25FNO4.Na" @default.
- NCIT_C29062 NCIT_P366 "Fluvastatin_Sodium" @default.
- NCIT_C29062 NCIT_P375 "Fluvastatin Sodium" @default.
- NCIT_C29062 NCIT_P399 "487588" @default.
- NCIT_C29062 normalizedInformationContent "100" @default.
- NCIT_C29062 referenceCount "1" @default.
- NCIT_C29062 hasExactSynonym "(3R,5S,6E)-(+/-)-7-(3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoic Acid" @default.
- NCIT_C29062 hasExactSynonym "FLUVASTATIN SODIUM" @default.
- NCIT_C29062 hasExactSynonym "Fluvastatin Sodium" @default.
- NCIT_C29062 hasExactSynonym "Lescol" @default.
- NCIT_C29062 inSubset NCIT_C116977 @default.
- NCIT_C29062 inSubset NCIT_C116978 @default.
- NCIT_C29062 inSubset NCIT_C128784 @default.
- NCIT_C29062 inSubset NCIT_C157711 @default.
- NCIT_C29062 inSubset NCIT_C157712 @default.
- NCIT_C29062 inSubset NCIT_C176424 @default.
- NCIT_C29062 inSubset NCIT_C177537 @default.
- NCIT_C29062 inSubset NCIT_C63923 @default.
- NCIT_C29062 type Class @default.
- NCIT_C29062 isDefinedBy ncit.owl @default.
- NCIT_C29062 label "Fluvastatin Sodium" @default.
- NCIT_C29062 subClassOf NCIT_C1655 @default.
- NCIT_C29062 subClassOf NCIT_C1908 @default.
- NCIT_C29062 subClassOf NCIT_C1909 @default.
- NCIT_C29062 subClassOf NCIT_C29062 @default.
- NCIT_C29062 subClassOf NCIT_C29703 @default.
- NCIT_C29062 subClassOf NCIT_C471 @default.
- NCIT_C29062 subClassOf NCIT_C78276 @default.