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- NCIT_C29076 IAO_0000115 "A sulfonamide urea derivative with antihyperglycemic activity that can potentially be used to decrease cerebral edema. Upon administration, glyburide binds to and blocks the sulfonylurea receptor type 1 (SUR1) subunit of the ATP-sensitive inwardly-rectifying potassium (K(ATP)) channels on the membranes of pancreatic beta cells. This prevents the inward current flow of positively charged potassium (K+) ions into the cell, and induces a calcium ion (Ca2+) influx through voltage-sensitive calcium channels, which triggers exocytosis of insulin-containing granules. In addition, glyburide also inhibits the SUR1-regulated nonselective cation (NC) Ca-ATP channel, melastatin 4 (transient receptor potential cation channel subfamily M member 4; (TRPM4)), thereby preventing capillary failure and brain swelling. SUR1-TRPM4 channels are formed by co-assembly of SUR1 with TRPM4 in neurons, astrocytes, and capillary endothelium during cerebral ischemia. Upon ischemia-induced ATP depletion, channels open which results in sodium influx, cytotoxic edema formation, capillary fragmentation and necrotic cell death. SUR1-TRPM4 is not expressed in normal, uninjured tissues." @default.
- NCIT_C29076 NCIT_NHC0 "C29076" @default.
- NCIT_C29076 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29076 NCIT_P107 "Glyburide" @default.
- NCIT_C29076 NCIT_P108 "Glyburide" @default.
- NCIT_C29076 NCIT_P207 "C0017628" @default.
- NCIT_C29076 NCIT_P210 "10238-21-8" @default.
- NCIT_C29076 NCIT_P319 "SX6K58TVWC" @default.
- NCIT_C29076 NCIT_P322 "CTRP" @default.
- NCIT_C29076 NCIT_P322 "FDA" @default.
- NCIT_C29076 NCIT_P329 "772960" @default.
- NCIT_C29076 NCIT_P330 "772960" @default.
- NCIT_C29076 NCIT_P350 "C23H28ClN3O5S" @default.
- NCIT_C29076 NCIT_P366 "Glyburide" @default.
- NCIT_C29076 NCIT_P368 "CHEBI:5441" @default.
- NCIT_C29076 NCIT_P399 "772960" @default.
- NCIT_C29076 NCIT_R122 NCIT_C16484 @default.
- NCIT_C29076 NCIT_R122 NCIT_C16486 @default.
- NCIT_C29076 NCIT_R122 NCIT_C16554 @default.
- NCIT_C29076 NCIT_R122 NCIT_C16865 @default.
- NCIT_C29076 NCIT_R122 NCIT_C16946 @default.
- NCIT_C29076 NCIT_R122 NCIT_C17021 @default.
- NCIT_C29076 NCIT_R122 NCIT_C20027 @default.
- NCIT_C29076 NCIT_R122 NCIT_C26548 @default.
- NCIT_C29076 NCIT_R122 NCIT_C28459 @default.
- NCIT_C29076 NCIT_R122 NCIT_C28750 @default.
- NCIT_C29076 normalizedInformationContent "100" @default.
- NCIT_C29076 referenceCount "1" @default.
- NCIT_C29076 hasExactSynonym "Diabeta" @default.
- NCIT_C29076 hasExactSynonym "GLYBURIDE" @default.
- NCIT_C29076 hasExactSynonym "Glibenclamide" @default.
- NCIT_C29076 hasExactSynonym "Glyburide" @default.
- NCIT_C29076 hasExactSynonym "Micronase" @default.
- NCIT_C29076 inSubset NCIT_C116977 @default.
- NCIT_C29076 inSubset NCIT_C116978 @default.
- NCIT_C29076 inSubset NCIT_C176424 @default.
- NCIT_C29076 inSubset NCIT_C63923 @default.
- NCIT_C29076 type Class @default.
- NCIT_C29076 isDefinedBy ncit.owl @default.
- NCIT_C29076 label "Glyburide" @default.
- NCIT_C29076 subClassOf B2ef267c4b27c162c5a67838bfb2b024e @default.
- NCIT_C29076 subClassOf B8986a27e916683f530cdee7b16954495 @default.
- NCIT_C29076 subClassOf NCIT_C1908 @default.
- NCIT_C29076 subClassOf NCIT_C1909 @default.
- NCIT_C29076 subClassOf NCIT_C29076 @default.
- NCIT_C29076 subClassOf NCIT_C29711 @default.
- NCIT_C29076 subClassOf NCIT_C78276 @default.
- NCIT_C29076 subClassOf NCIT_C97936 @default.