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- NCIT_C29095 IAO_0000115 "An immunoconjugate comprised of a humanized monoclonal antibody with antitumor activity. The monoclonal antibody CC49 is developed from the murine monoclonal antibody B72.3 and is humanized by grafting the hypervariable regions onto the variable light (VL) and variable heavy (VH) frameworks of the monoclonal antibodies LEN and 21/28' CL. In addition the CH2 domain in the constant region is deleted to increase plasma clearance. The resultant antibody binds to the pancarcinoma tumor-associated glycoprotein (TAG)-72 with high affinity. Furthermore, the antibody is conjugated to PA-DOTA, a bifunctional chelating agent and commonly radiolabeled, resulting in an effective agent for radioimmunotherapy." @default.
- NCIT_C29095 NCIT_NHC0 "C29095" @default.
- NCIT_C29095 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29095 NCIT_P108 "HuCC49deltaCH2-PA-DOTA" @default.
- NCIT_C29095 NCIT_P175 "719644" @default.
- NCIT_C29095 NCIT_P207 "C1512504" @default.
- NCIT_C29095 NCIT_P366 "HuCC49deltaCH2-PA-DOTA" @default.
- NCIT_C29095 NCIT_R124 NCIT_C17710 @default.
- NCIT_C29095 NCIT_R124 NCIT_C17828 @default.
- NCIT_C29095 NCIT_R124 NCIT_C18219 @default.
- NCIT_C29095 NCIT_R124 NCIT_C19986 @default.
- NCIT_C29095 NCIT_R124 NCIT_C40474 @default.
- NCIT_C29095 NCIT_R125 NCIT_C17828 @default.
- NCIT_C29095 NCIT_R125 NCIT_C17937 @default.
- NCIT_C29095 NCIT_R125 NCIT_C18095 @default.
- NCIT_C29095 NCIT_R125 NCIT_C18839 @default.
- NCIT_C29095 NCIT_R125 NCIT_C21124 @default.
- NCIT_C29095 NCIT_R125 NCIT_C40912 @default.
- NCIT_C29095 normalizedInformationContent "100" @default.
- NCIT_C29095 referenceCount "1" @default.
- NCIT_C29095 hasExactSynonym "HuCC49DCH2-PA-DOTA" @default.
- NCIT_C29095 hasExactSynonym "HuCC49deltaCH2-PA-DOTA" @default.
- NCIT_C29095 inSubset NCIT_C128784 @default.
- NCIT_C29095 type Class @default.
- NCIT_C29095 isDefinedBy ncit.owl @default.
- NCIT_C29095 label "HuCC49deltaCH2-PA-DOTA" @default.
- NCIT_C29095 subClassOf NCIT_C1512 @default.
- NCIT_C29095 subClassOf NCIT_C1908 @default.
- NCIT_C29095 subClassOf NCIT_C1909 @default.
- NCIT_C29095 subClassOf NCIT_C2747 @default.
- NCIT_C29095 subClassOf NCIT_C29095 @default.
- NCIT_C29095 subClassOf NCIT_C307 @default.
- NCIT_C29095 subClassOf NCIT_C308 @default.