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- NCIT_C29103 IAO_0000115 "A piperazine derivative with antihistamine, antiemetic, and anxiolytic properties. Hydroxyzine's antihistaminic effect is due to its metabolite, cetirizine, a potent H1 receptor antagonist and selective inhibitor of peripheral H1 receptors. This agent competes with histamine for binding at H1-receptor sites on the effector cell surface. The sedative properties of hydroxyzine occur as a result of suppression of certain subcortical regions of the brain. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic." @default.
- NCIT_C29103 NCIT_A5 NCIT_C47559 @default.
- NCIT_C29103 NCIT_A5 NCIT_C47560 @default.
- NCIT_C29103 NCIT_NHC0 "C29103" @default.
- NCIT_C29103 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29103 NCIT_P108 "Hydroxyzine" @default.
- NCIT_C29103 NCIT_P175 "169188" @default.
- NCIT_C29103 NCIT_P207 "C0020404" @default.
- NCIT_C29103 NCIT_P210 "68-88-2" @default.
- NCIT_C29103 NCIT_P319 "30S50YM8OG" @default.
- NCIT_C29103 NCIT_P322 "FDA" @default.
- NCIT_C29103 NCIT_P350 "C21H27ClN2O2" @default.
- NCIT_C29103 NCIT_P366 "Hydroxyzine" @default.
- NCIT_C29103 NCIT_P368 "CHEBI:5818" @default.
- NCIT_C29103 normalizedInformationContent "100" @default.
- NCIT_C29103 referenceCount "1" @default.
- NCIT_C29103 hasExactSynonym "HYDROXYZINE" @default.
- NCIT_C29103 hasExactSynonym "Hydroxyzine" @default.
- NCIT_C29103 inSubset NCIT_C63923 @default.
- NCIT_C29103 type Class @default.
- NCIT_C29103 isDefinedBy ncit.owl @default.
- NCIT_C29103 label "Hydroxyzine" @default.
- NCIT_C29103 subClassOf NCIT_C1908 @default.
- NCIT_C29103 subClassOf NCIT_C1909 @default.
- NCIT_C29103 subClassOf NCIT_C29103 @default.
- NCIT_C29103 subClassOf NCIT_C29578 @default.
- NCIT_C29103 subClassOf NCIT_C308 @default.