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- NCIT_C29115 IAO_0000115 "A 2-cyanoaziridine derivative with antitumor activity in multiple myeloma. Although its mechanism of action is not clearly known, imexon may induce apoptosis via a pathway involving cleaved caspase-3, caspase-9, and/or caspase-8. Other cytotoxic mechanisms of action of this agent may involve thiol depletion, generation of reactive oxygen species (ROS), and decreases in the mitochondrial membrane potential. (NCI04)" @default.
- NCIT_C29115 NCIT_A32 NCIT_C1909 @default.
- NCIT_C29115 NCIT_NHC0 "C29115" @default.
- NCIT_C29115 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29115 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29115 NCIT_P107 "Imexon" @default.
- NCIT_C29115 NCIT_P108 "Imexon" @default.
- NCIT_C29115 NCIT_P175 "714597" @default.
- NCIT_C29115 NCIT_P207 "C0097147" @default.
- NCIT_C29115 NCIT_P210 "59643-91-3" @default.
- NCIT_C29115 NCIT_P319 "8F63U28T2V" @default.
- NCIT_C29115 NCIT_P322 "CTRP" @default.
- NCIT_C29115 NCIT_P322 "FDA" @default.
- NCIT_C29115 NCIT_P322 "GDC" @default.
- NCIT_C29115 NCIT_P325 "A substance that is being studied in the treatment of some types of cancer, including pancreatic, lung, breast, prostate, melanoma, and multiple myeloma. It belongs to the family of drugs called cyanoaziridine derivatives." @default.
- NCIT_C29115 NCIT_P329 "468469" @default.
- NCIT_C29115 NCIT_P330 "468469" @default.
- NCIT_C29115 NCIT_P350 "C4H5N3O" @default.
- NCIT_C29115 NCIT_P366 "Imexon" @default.
- NCIT_C29115 NCIT_P375 "Imexon" @default.
- NCIT_C29115 NCIT_P399 "468469" @default.
- NCIT_C29115 NCIT_R124 NCIT_C17710 @default.
- NCIT_C29115 NCIT_R124 NCIT_C17828 @default.
- NCIT_C29115 NCIT_R124 NCIT_C19986 @default.
- NCIT_C29115 NCIT_R124 NCIT_C40551 @default.
- NCIT_C29115 NCIT_R125 NCIT_C17710 @default.
- NCIT_C29115 NCIT_R125 NCIT_C17828 @default.
- NCIT_C29115 NCIT_R125 NCIT_C19536 @default.
- NCIT_C29115 NCIT_R125 NCIT_C19656 @default.
- NCIT_C29115 NCIT_R125 NCIT_C20150 @default.
- NCIT_C29115 NCIT_R125 NCIT_C20480 @default.
- NCIT_C29115 NCIT_R125 NCIT_C21040 @default.
- NCIT_C29115 NCIT_R125 NCIT_C28498 @default.
- NCIT_C29115 NCIT_R125 NCIT_C40715 @default.
- NCIT_C29115 NCIT_R125 NCIT_C41515 @default.
- NCIT_C29115 NCIT_R125 NCIT_C41583 @default.
- NCIT_C29115 NCIT_R125 NCIT_C51037 @default.
- NCIT_C29115 normalizedInformationContent "100" @default.
- NCIT_C29115 referenceCount "1" @default.
- NCIT_C29115 hasExactSynonym "4-imino-1,3-diazabicyclo[3,1,0]-hexan-2-one" @default.
- NCIT_C29115 hasExactSynonym "Amplimexon" @default.
- NCIT_C29115 hasExactSynonym "IMEXON" @default.
- NCIT_C29115 hasExactSynonym "Imexon" @default.
- NCIT_C29115 hasExactSynonym "imexon" @default.
- NCIT_C29115 inSubset NCIT_C116977 @default.
- NCIT_C29115 inSubset NCIT_C116978 @default.
- NCIT_C29115 inSubset NCIT_C128784 @default.
- NCIT_C29115 inSubset NCIT_C157711 @default.
- NCIT_C29115 inSubset NCIT_C157712 @default.
- NCIT_C29115 inSubset NCIT_C176424 @default.
- NCIT_C29115 inSubset NCIT_C177537 @default.
- NCIT_C29115 inSubset NCIT_C63923 @default.
- NCIT_C29115 type Class @default.
- NCIT_C29115 isDefinedBy ncit.owl @default.
- NCIT_C29115 label "Imexon" @default.
- NCIT_C29115 subClassOf B07e6d4c35ab3812667474a1ef0d649c7 @default.
- NCIT_C29115 subClassOf B24b6bbc714118cba458fbabddd86fee4 @default.
- NCIT_C29115 subClassOf B4d978fcee24287f0cc5b2b3405a790a5 @default.
- NCIT_C29115 subClassOf B9714c8a6c6a06cb69390acd957d20762 @default.
- NCIT_C29115 subClassOf Bb14a979d8516ffe74f34a5c6e6ae54f8 @default.
- NCIT_C29115 subClassOf Bc3c6bd80ab0e0590eaedf8a3b0f82941 @default.
- NCIT_C29115 subClassOf Bf12bde2c2352996ceef4d240a8a8c6ea @default.
- NCIT_C29115 subClassOf Bf194e5e11f1c7b187a117f613160aec9 @default.
- NCIT_C29115 subClassOf NCIT_C1908 @default.
- NCIT_C29115 subClassOf NCIT_C1909 @default.
- NCIT_C29115 subClassOf NCIT_C29115 @default.
- NCIT_C29115 subClassOf NCIT_C308 @default.