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- NCIT_C29134 IAO_0000115 "The dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide dinitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide dinitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05)" @default.
- NCIT_C29134 NCIT_A6 NCIT_C60773 @default.
- NCIT_C29134 NCIT_NHC0 "C29134" @default.
- NCIT_C29134 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29134 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29134 NCIT_P108 "Isosorbide Dinitrate" @default.
- NCIT_C29134 NCIT_P175 "80038" @default.
- NCIT_C29134 NCIT_P207 "C0022252" @default.
- NCIT_C29134 NCIT_P210 "87-33-2" @default.
- NCIT_C29134 NCIT_P319 "IA7306519N" @default.
- NCIT_C29134 NCIT_P322 "FDA" @default.
- NCIT_C29134 NCIT_P350 "C6H8N2O8" @default.
- NCIT_C29134 NCIT_P366 "Isosorbide_Dinitrate" @default.
- NCIT_C29134 NCIT_P368 "CHEBI:6061" @default.
- NCIT_C29134 normalizedInformationContent "100" @default.
- NCIT_C29134 referenceCount "1" @default.
- NCIT_C29134 hasExactSynonym "ISOSORBIDE DINITRATE" @default.
- NCIT_C29134 hasExactSynonym "Isordil" @default.
- NCIT_C29134 hasExactSynonym "Isosorbide Dinitrate" @default.
- NCIT_C29134 inSubset NCIT_C63923 @default.
- NCIT_C29134 type Class @default.
- NCIT_C29134 isDefinedBy ncit.owl @default.
- NCIT_C29134 label "Isosorbide Dinitrate" @default.
- NCIT_C29134 subClassOf NCIT_C1908 @default.
- NCIT_C29134 subClassOf NCIT_C1909 @default.
- NCIT_C29134 subClassOf NCIT_C29134 @default.
- NCIT_C29134 subClassOf NCIT_C29707 @default.
- NCIT_C29134 subClassOf NCIT_C78274 @default.