Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C29230> ?p ?o ?g. }
Showing items 1 to 30 of
30
with 100 items per page.
- NCIT_C29230 IAO_0000115 "A radioimmunoconjugate comprised of daclizumab, a recombinant humanized monoclonal antibody directed against the alpha subunit of the interleukin-2 (IL-2) receptor (IL-2RA, TAC antigen, CD25), which is labeled with the gamma-emitting isotope indium 111 (In 111; 111In), with potential radioimaging application. Upon administration, indium In 111 daclizumab targets and binds to IL-2RA and inhibits the binding of IL-2, thereby blocking IL-2-mediated activation of lymphocytes. IL-2RA is not expressed by normal resting lymphoid cells, with the exception of regulatory T-cells (Tregs), but it is expressed on a minority of Reed-Sternberg cells and, is overexpressed on T-cells rosetting around Reed-Sternberg cells in certain lymphomas. The use of gamma scintigraphy permits the immunodetection of IL-2RA expressing cells." @default.
- NCIT_C29230 NCIT_A7 NCIT_C17073 @default.
- NCIT_C29230 NCIT_NHC0 "C29230" @default.
- NCIT_C29230 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C29230 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29230 NCIT_P107 "Indium In 111 Daclizumab" @default.
- NCIT_C29230 NCIT_P108 "Indium In 111 Daclizumab" @default.
- NCIT_C29230 NCIT_P207 "C1512687" @default.
- NCIT_C29230 NCIT_P322 "CTRP" @default.
- NCIT_C29230 normalizedInformationContent "100" @default.
- NCIT_C29230 referenceCount "1" @default.
- NCIT_C29230 hasExactSynonym "In-111-Daclizumab" @default.
- NCIT_C29230 hasExactSynonym "In111 Daclizumab" @default.
- NCIT_C29230 hasExactSynonym "In111 MoAb Anti-TAC" @default.
- NCIT_C29230 hasExactSynonym "Indium In 111 Daclizumab" @default.
- NCIT_C29230 hasExactSynonym "MOAB TAC-111IN" @default.
- NCIT_C29230 inSubset NCIT_C116977 @default.
- NCIT_C29230 inSubset NCIT_C116978 @default.
- NCIT_C29230 type Class @default.
- NCIT_C29230 isDefinedBy ncit.owl @default.
- NCIT_C29230 label "Indium In 111 Daclizumab" @default.
- NCIT_C29230 subClassOf NCIT_C1446 @default.
- NCIT_C29230 subClassOf NCIT_C1511 @default.
- NCIT_C29230 subClassOf NCIT_C1512 @default.
- NCIT_C29230 subClassOf NCIT_C1908 @default.
- NCIT_C29230 subClassOf NCIT_C1909 @default.
- NCIT_C29230 subClassOf NCIT_C2124 @default.
- NCIT_C29230 subClassOf NCIT_C29230 @default.
- NCIT_C29230 subClassOf NCIT_C307 @default.
- NCIT_C29230 subClassOf NCIT_C308 @default.