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- NCIT_C29251 IAO_0000115 "The hydrochloride salt of the biguanide metformin with antihyperglycemic and potential antineoplastic activities. Metformin inhibits complex I (NADPH:ubiquinone oxidoreductase) of the mitochondrial respiratory chain, thereby increasing the cellular AMP to ATP ratio and leading to activation of AMP-activated protein kinase (AMPK) and regulating AMPK-mediated transcription of target genes. This eventually prevents hepatic gluconeogenesis, enhances insulin sensitivity and fatty acid oxidation and ultimately leads to a decrease in glucose levels. Metformin may exert antineoplastic effects through AMPK-mediated or AMPK-independent inhibition of mammalian target of rapamycin (mTOR), which is up-regulated in many cancer tissues. Furthermore, this agent also inhibits tumor cell migration and invasion by inhibiting matrix metalloproteinase-9 (MMP-9) expression which is mediated through the suppression of transcription activator protein-1 (AP-1) activation." @default.
- NCIT_C29251 NCIT_A32 NCIT_C1909 @default.
- NCIT_C29251 NCIT_A6 NCIT_C61612 @default.
- NCIT_C29251 NCIT_A7 NCIT_C118184 @default.
- NCIT_C29251 NCIT_A7 NCIT_C94701 @default.
- NCIT_C29251 NCIT_NHC0 "C29251" @default.
- NCIT_C29251 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29251 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29251 NCIT_P107 "Metformin Hydrochloride" @default.
- NCIT_C29251 NCIT_P108 "Metformin Hydrochloride" @default.
- NCIT_C29251 NCIT_P175 "91485" @default.
- NCIT_C29251 NCIT_P207 "C0770893" @default.
- NCIT_C29251 NCIT_P210 "1115-70-4" @default.
- NCIT_C29251 NCIT_P319 "786Z46389E" @default.
- NCIT_C29251 NCIT_P322 "CTRP" @default.
- NCIT_C29251 NCIT_P322 "FDA" @default.
- NCIT_C29251 NCIT_P322 "GDC" @default.
- NCIT_C29251 NCIT_P325 "A drug used to treat diabetes mellitus (a condition in which the body cannot control the level of sugar in the blood). It is also being studied in the treatment of cancer. It decreases the amount of glucose (a type of sugar) released into the bloodstream from the liver and increases the body's use of the glucose. Glucophage is a type of antidiabetic agent." @default.
- NCIT_C29251 NCIT_P329 "593641" @default.
- NCIT_C29251 NCIT_P330 "593641" @default.
- NCIT_C29251 NCIT_P350 "C4H11N5.HCl" @default.
- NCIT_C29251 NCIT_P366 "Metformin_Hydrochloride" @default.
- NCIT_C29251 NCIT_P375 "Metformin Hydrochloride" @default.
- NCIT_C29251 NCIT_P399 "593641" @default.
- NCIT_C29251 normalizedInformationContent "100" @default.
- NCIT_C29251 referenceCount "1" @default.
- NCIT_C29251 hasExactSynonym "1,1-Dimethylbiguanide Hydrochloride" @default.
- NCIT_C29251 hasExactSynonym "APO-Metformin" @default.
- NCIT_C29251 hasExactSynonym "Cidophage" @default.
- NCIT_C29251 hasExactSynonym "Dimefor" @default.
- NCIT_C29251 hasExactSynonym "Glifage" @default.
- NCIT_C29251 hasExactSynonym "Glucoformin" @default.
- NCIT_C29251 hasExactSynonym "Glucophage ER" @default.
- NCIT_C29251 hasExactSynonym "Glucophage" @default.
- NCIT_C29251 hasExactSynonym "METFORMIN HYDROCHLORIDE" @default.
- NCIT_C29251 hasExactSynonym "Metformin HCl" @default.
- NCIT_C29251 hasExactSynonym "Metformin Hydrochloride" @default.
- NCIT_C29251 hasExactSynonym "N,N-Dimethylimidodicarbonimidic Diamide Monohydrochloride" @default.
- NCIT_C29251 hasExactSynonym "Riomet" @default.
- NCIT_C29251 hasExactSynonym "Siofor" @default.
- NCIT_C29251 hasExactSynonym "metformin hydrochloride" @default.
- NCIT_C29251 inSubset NCIT_C116977 @default.
- NCIT_C29251 inSubset NCIT_C116978 @default.
- NCIT_C29251 inSubset NCIT_C128784 @default.
- NCIT_C29251 inSubset NCIT_C157711 @default.
- NCIT_C29251 inSubset NCIT_C157712 @default.
- NCIT_C29251 inSubset NCIT_C173381 @default.
- NCIT_C29251 inSubset NCIT_C173383 @default.
- NCIT_C29251 inSubset NCIT_C176424 @default.
- NCIT_C29251 inSubset NCIT_C177537 @default.
- NCIT_C29251 inSubset NCIT_C63923 @default.
- NCIT_C29251 type Class @default.
- NCIT_C29251 isDefinedBy ncit.owl @default.
- NCIT_C29251 label "Metformin Hydrochloride" @default.
- NCIT_C29251 subClassOf NCIT_C1892 @default.
- NCIT_C29251 subClassOf NCIT_C1908 @default.
- NCIT_C29251 subClassOf NCIT_C1909 @default.
- NCIT_C29251 subClassOf NCIT_C29251 @default.
- NCIT_C29251 subClassOf NCIT_C29711 @default.
- NCIT_C29251 subClassOf NCIT_C78276 @default.
- NCIT_C29251 subClassOf NCIT_C98234 @default.