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- NCIT_C29261 IAO_0000115 "A substance derived from any of several Old World coarse prickly-leaved shrubs and subshrubs including the plant Silybum marianum. Milk thistle's active chemical component is silymarin, which is a combination of flavonoids such as silibinin, dehydrosilibinin, silychristin and silydianin. These compounds are antioxidants and may alter the membrane structure of the liver cell, thereby blocking the absorption of toxins; they may also stimulate the production of new liver cells. In addition, milk thistle may increase cellular adenosine triphosphate (ATP) levels, exhibiting dose-dependent cardiac myocyte cytoprotection against doxorubicin. The silibinin component of milk thistle has been shown to inhibit growth factor receptor-mediated mitogenic and cell survival signaling, thereby inhibiting tumor growth. (NCI04)" @default.
- NCIT_C29261 NCIT_A32 NCIT_C1909 @default.
- NCIT_C29261 NCIT_NHC0 "C29261" @default.
- NCIT_C29261 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29261 NCIT_P108 "Milk Thistle" @default.
- NCIT_C29261 NCIT_P207 "C0937640" @default.
- NCIT_C29261 NCIT_P210 "65666-07-1" @default.
- NCIT_C29261 NCIT_P319 "U946SH95EE" @default.
- NCIT_C29261 NCIT_P322 "FDA" @default.
- NCIT_C29261 NCIT_P322 "GDC" @default.
- NCIT_C29261 NCIT_P325 "A plant that has been used in some cultures to treat certain medical problems, including stomach, liver, and gallbladder disorders. The active extract of milk thistle seeds is called silymarin. It is being studied in the prevention of liver damage caused by some cancer treatments." @default.
- NCIT_C29261 NCIT_P329 "459958" @default.
- NCIT_C29261 NCIT_P330 "459958" @default.
- NCIT_C29261 NCIT_P366 "Milk_Thistle" @default.
- NCIT_C29261 NCIT_P375 "Milk Thistle" @default.
- NCIT_C29261 NCIT_P399 "459958" @default.
- NCIT_C29261 normalizedInformationContent "100" @default.
- NCIT_C29261 referenceCount "1" @default.
- NCIT_C29261 hasExactSynonym "MILK THISTLE" @default.
- NCIT_C29261 hasExactSynonym "Milk Thistle" @default.
- NCIT_C29261 hasExactSynonym "milk thistle" @default.
- NCIT_C29261 inSubset NCIT_C128784 @default.
- NCIT_C29261 inSubset NCIT_C157711 @default.
- NCIT_C29261 inSubset NCIT_C157712 @default.
- NCIT_C29261 inSubset NCIT_C176424 @default.
- NCIT_C29261 inSubset NCIT_C177537 @default.
- NCIT_C29261 inSubset NCIT_C63923 @default.
- NCIT_C29261 type Class @default.
- NCIT_C29261 isDefinedBy ncit.owl @default.
- NCIT_C29261 label "Milk Thistle" @default.
- NCIT_C29261 subClassOf NCIT_C106104 @default.
- NCIT_C29261 subClassOf NCIT_C1908 @default.
- NCIT_C29261 subClassOf NCIT_C1909 @default.
- NCIT_C29261 subClassOf NCIT_C26170 @default.
- NCIT_C29261 subClassOf NCIT_C275 @default.
- NCIT_C29261 subClassOf NCIT_C29261 @default.
- NCIT_C29261 subClassOf NCIT_C66892 @default.