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- NCIT_C29267 IAO_0000115 "The hydrochloride salt form of moexipril, a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Moexipril hydrochloride is hydrolized into its active form moexiprilat, which competitively inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the actions of the potent vasoconstrictor angiotensin II and leads to vasodilatation. It also prevents angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. Moexipril hydrochloride also directly suppresses renin release." @default.
- NCIT_C29267 NCIT_A6 NCIT_C83967 @default.
- NCIT_C29267 NCIT_NHC0 "C29267" @default.
- NCIT_C29267 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29267 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29267 NCIT_P108 "Moexipril Hydrochloride" @default.
- NCIT_C29267 NCIT_P207 "C0771294" @default.
- NCIT_C29267 NCIT_P210 "82586-52-5" @default.
- NCIT_C29267 NCIT_P319 "Q1UMG3UH45" @default.
- NCIT_C29267 NCIT_P322 "FDA" @default.
- NCIT_C29267 NCIT_P350 "C27H34N2O7.HCl" @default.
- NCIT_C29267 NCIT_P366 "Moexipril_Hydrochloride" @default.
- NCIT_C29267 normalizedInformationContent "100" @default.
- NCIT_C29267 referenceCount "1" @default.
- NCIT_C29267 hasExactSynonym "MOEXIPRIL HYDROCHLORIDE" @default.
- NCIT_C29267 hasExactSynonym "Moexipril HCl" @default.
- NCIT_C29267 hasExactSynonym "Moexipril Hydrochloride" @default.
- NCIT_C29267 hasExactSynonym "Univasc" @default.
- NCIT_C29267 inSubset NCIT_C63923 @default.
- NCIT_C29267 type Class @default.
- NCIT_C29267 isDefinedBy ncit.owl @default.
- NCIT_C29267 label "Moexipril Hydrochloride" @default.
- NCIT_C29267 subClassOf NCIT_C1908 @default.
- NCIT_C29267 subClassOf NCIT_C1909 @default.
- NCIT_C29267 subClassOf NCIT_C247 @default.
- NCIT_C29267 subClassOf NCIT_C270 @default.
- NCIT_C29267 subClassOf NCIT_C29267 @default.
- NCIT_C29267 subClassOf NCIT_C471 @default.
- NCIT_C29267 subClassOf NCIT_C78274 @default.
- NCIT_C29267 subClassOf NCIT_C783 @default.