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- NCIT_C29280 IAO_0000115 "A non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. Nadolol competitively blocks beta-1 adrenergic receptors located in the heart and vascular smooth muscle, inhibiting the activities of the catecholamines epinephrine and norepinephrine and producing negative inotropic and chronotropic effects. This agent exhibits antiarrhythmic activity via the impairment of atrioventricular (AV) node conduction and a corresponding reduction in sinus rate. In the kidney, inhibition of the beta-2 receptor within the juxtaglomerular apparatus results in the inhibition of renin production and a subsequent reduction in angiotensin II and aldosterone levels, thus inhibiting angiotensin II-dependent vasoconstriction and aldosterone-dependent water retention." @default.
- NCIT_C29280 NCIT_NHC0 "C29280" @default.
- NCIT_C29280 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29280 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29280 NCIT_P108 "Nadolol" @default.
- NCIT_C29280 NCIT_P207 "C0027302" @default.
- NCIT_C29280 NCIT_P210 "42200-33-9" @default.
- NCIT_C29280 NCIT_P319 "FEN504330V" @default.
- NCIT_C29280 NCIT_P322 "FDA" @default.
- NCIT_C29280 NCIT_P329 "659002" @default.
- NCIT_C29280 NCIT_P330 "659002" @default.
- NCIT_C29280 NCIT_P366 "Nadolol" @default.
- NCIT_C29280 NCIT_P368 "CHEBI:7444" @default.
- NCIT_C29280 NCIT_P399 "659002" @default.
- NCIT_C29280 normalizedInformationContent "100" @default.
- NCIT_C29280 referenceCount "1" @default.
- NCIT_C29280 hasExactSynonym "Corgard" @default.
- NCIT_C29280 hasExactSynonym "NADOLOL" @default.
- NCIT_C29280 hasExactSynonym "Nadolol" @default.
- NCIT_C29280 inSubset NCIT_C176424 @default.
- NCIT_C29280 inSubset NCIT_C63923 @default.
- NCIT_C29280 type Class @default.
- NCIT_C29280 isDefinedBy ncit.owl @default.
- NCIT_C29280 label "Nadolol" @default.
- NCIT_C29280 subClassOf NCIT_C1908 @default.
- NCIT_C29280 subClassOf NCIT_C1909 @default.
- NCIT_C29280 subClassOf NCIT_C29280 @default.
- NCIT_C29280 subClassOf NCIT_C29576 @default.
- NCIT_C29280 subClassOf NCIT_C29747 @default.
- NCIT_C29280 subClassOf NCIT_C72900 @default.
- NCIT_C29280 subClassOf NCIT_C78272 @default.