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- NCIT_C29309 IAO_0000115 "A semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability." @default.
- NCIT_C29309 NCIT_A5 NCIT_C48009 @default.
- NCIT_C29309 NCIT_A5 NCIT_C48010 @default.
- NCIT_C29309 NCIT_NHC0 "C29309" @default.
- NCIT_C29309 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29309 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29309 NCIT_P107 "Oxycodone" @default.
- NCIT_C29309 NCIT_P108 "Oxycodone" @default.
- NCIT_C29309 NCIT_P175 "19043" @default.
- NCIT_C29309 NCIT_P207 "C0030049" @default.
- NCIT_C29309 NCIT_P210 "76-42-6" @default.
- NCIT_C29309 NCIT_P319 "CD35PMG570" @default.
- NCIT_C29309 NCIT_P322 "CTRP" @default.
- NCIT_C29309 NCIT_P322 "FDA" @default.
- NCIT_C29309 NCIT_P350 "C18H21NO4" @default.
- NCIT_C29309 NCIT_P366 "Oxycodone" @default.
- NCIT_C29309 NCIT_P368 "CHEBI:7852" @default.
- NCIT_C29309 NCIT_R122 NCIT_C16484 @default.
- NCIT_C29309 NCIT_R122 NCIT_C16486 @default.
- NCIT_C29309 NCIT_R122 NCIT_C16554 @default.
- NCIT_C29309 NCIT_R122 NCIT_C16865 @default.
- NCIT_C29309 NCIT_R122 NCIT_C16946 @default.
- NCIT_C29309 NCIT_R122 NCIT_C17021 @default.
- NCIT_C29309 NCIT_R122 NCIT_C17287 @default.
- NCIT_C29309 NCIT_R122 NCIT_C20027 @default.
- NCIT_C29309 NCIT_R122 NCIT_C26548 @default.
- NCIT_C29309 NCIT_R122 NCIT_C28459 @default.
- NCIT_C29309 normalizedInformationContent "100" @default.
- NCIT_C29309 referenceCount "1" @default.
- NCIT_C29309 hasExactSynonym "4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one" @default.
- NCIT_C29309 hasExactSynonym "OXYCODONE" @default.
- NCIT_C29309 hasExactSynonym "Oxycodone SR" @default.
- NCIT_C29309 hasExactSynonym "Oxycodone" @default.
- NCIT_C29309 inSubset NCIT_C116977 @default.
- NCIT_C29309 inSubset NCIT_C116978 @default.
- NCIT_C29309 inSubset NCIT_C63923 @default.
- NCIT_C29309 type Class @default.
- NCIT_C29309 isDefinedBy ncit.owl @default.
- NCIT_C29309 label "Oxycodone" @default.
- NCIT_C29309 subClassOf B5375b90ec0656c341c7c08396ebc27ce @default.
- NCIT_C29309 subClassOf B774fcddfe432b6d74db7a8c242977e75 @default.
- NCIT_C29309 subClassOf NCIT_C1506 @default.
- NCIT_C29309 subClassOf NCIT_C1908 @default.
- NCIT_C29309 subClassOf NCIT_C1909 @default.
- NCIT_C29309 subClassOf NCIT_C1913 @default.
- NCIT_C29309 subClassOf NCIT_C1916 @default.
- NCIT_C29309 subClassOf NCIT_C221 @default.
- NCIT_C29309 subClassOf NCIT_C29309 @default.
- NCIT_C29309 subClassOf NCIT_C67413 @default.
- NCIT_C29309 subClassOf NCIT_C718 @default.
- NCIT_C29309 subClassOf NCIT_C78272 @default.