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- NCIT_C29322 IAO_0000115 "One of a number of chemically-related alkylating agents with antineoplastic properties. The prototype of this group of agents is cyclophosphamide. Most phosphoramide mustards are administered as prodrugs that undergo reductive activation in hypoxic environments to yield cytotoxic metabolites. These agents alkylate and crosslink DNA, resulting in inhibition of DNA replication. Phosphoramide mustards are also immunosuppressants, mutagens and teratogens. (NCI04)" @default.
- NCIT_C29322 NCIT_A32 NCIT_C1909 @default.
- NCIT_C29322 NCIT_NHC0 "C29322" @default.
- NCIT_C29322 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29322 NCIT_P108 "Phosphoramide Mustard" @default.
- NCIT_C29322 NCIT_P207 "C0070913" @default.
- NCIT_C29322 NCIT_P322 "GDC" @default.
- NCIT_C29322 NCIT_P366 "Phosphoramide_Mustard" @default.
- NCIT_C29322 NCIT_P368 "CHEBI:8163" @default.
- NCIT_C29322 NCIT_P375 "Phosphoramide Mustard" @default.
- NCIT_C29322 normalizedInformationContent "100" @default.
- NCIT_C29322 referenceCount "1" @default.
- NCIT_C29322 hasExactSynonym "Phosphoramide Mustard" @default.
- NCIT_C29322 inSubset NCIT_C128784 @default.
- NCIT_C29322 inSubset NCIT_C157711 @default.
- NCIT_C29322 inSubset NCIT_C157712 @default.
- NCIT_C29322 inSubset NCIT_C177537 @default.
- NCIT_C29322 type Class @default.
- NCIT_C29322 isDefinedBy ncit.owl @default.
- NCIT_C29322 label "Phosphoramide Mustard" @default.
- NCIT_C29322 subClassOf NCIT_C1590 @default.
- NCIT_C29322 subClassOf NCIT_C186664 @default.
- NCIT_C29322 subClassOf NCIT_C1908 @default.
- NCIT_C29322 subClassOf NCIT_C1909 @default.
- NCIT_C29322 subClassOf NCIT_C2114 @default.
- NCIT_C29322 subClassOf NCIT_C274 @default.
- NCIT_C29322 subClassOf NCIT_C2842 @default.
- NCIT_C29322 subClassOf NCIT_C29322 @default.
- NCIT_C29322 subClassOf NCIT_C308 @default.
- NCIT_C29322 subClassOf NCIT_C574 @default.
- NCIT_C29322 subClassOf NCIT_C697 @default.