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- NCIT_C29355 IAO_0000115 "A phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. Perphenazine blocks postsynaptic dopamine 2(D2) receptors in the mesolimbic and medullary chemoreceptor trigger zone (CTZ), thereby preventing the excess of dopamine in the brain. This leads to reduction in psychotic symptoms, such as hallucinations and delusions. Perphenazine appears to exert its antiemetic activity by blocking the dopamine and histamine-1 receptor in the CTZ thereby relieving nausea and vomiting in the brain. In addition, perphenazine binds to alpha-adrenergic receptors." @default.
- NCIT_C29355 NCIT_NHC0 "C29355" @default.
- NCIT_C29355 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29355 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29355 NCIT_P108 "Perphenazine" @default.
- NCIT_C29355 NCIT_P175 "150866" @default.
- NCIT_C29355 NCIT_P207 "C0031184" @default.
- NCIT_C29355 NCIT_P210 "58-39-9" @default.
- NCIT_C29355 NCIT_P319 "FTA7XXY4EZ" @default.
- NCIT_C29355 NCIT_P322 "FDA" @default.
- NCIT_C29355 NCIT_P350 "C21H26ClN3OS" @default.
- NCIT_C29355 NCIT_P366 "Perphenazine" @default.
- NCIT_C29355 NCIT_P368 "CHEBI:8028" @default.
- NCIT_C29355 NCIT_R122 NCIT_C16484 @default.
- NCIT_C29355 NCIT_R122 NCIT_C16486 @default.
- NCIT_C29355 NCIT_R122 NCIT_C16554 @default.
- NCIT_C29355 NCIT_R122 NCIT_C16865 @default.
- NCIT_C29355 NCIT_R122 NCIT_C16946 @default.
- NCIT_C29355 NCIT_R122 NCIT_C17021 @default.
- NCIT_C29355 NCIT_R122 NCIT_C17287 @default.
- NCIT_C29355 NCIT_R122 NCIT_C20027 @default.
- NCIT_C29355 NCIT_R122 NCIT_C26548 @default.
- NCIT_C29355 NCIT_R122 NCIT_C28459 @default.
- NCIT_C29355 normalizedInformationContent "100" @default.
- NCIT_C29355 referenceCount "1" @default.
- NCIT_C29355 hasExactSynonym "4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol" @default.
- NCIT_C29355 hasExactSynonym "PERPHENAZINE" @default.
- NCIT_C29355 hasExactSynonym "Perphenazine" @default.
- NCIT_C29355 inSubset NCIT_C63923 @default.
- NCIT_C29355 type Class @default.
- NCIT_C29355 isDefinedBy ncit.owl @default.
- NCIT_C29355 label "Perphenazine" @default.
- NCIT_C29355 subClassOf B456ece28a20a5112b9f385fe54d27a6c @default.
- NCIT_C29355 subClassOf B6386473277b9f2027c31faace4284565 @default.
- NCIT_C29355 subClassOf NCIT_C1908 @default.
- NCIT_C29355 subClassOf NCIT_C1909 @default.
- NCIT_C29355 subClassOf NCIT_C29355 @default.
- NCIT_C29355 subClassOf NCIT_C29710 @default.
- NCIT_C29355 subClassOf NCIT_C78272 @default.