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- NCIT_C29375 IAO_0000115 "The sodium salt of pravastatin with cholesterol-lowering and potential antineoplastic activities. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. In addition, pravastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cells; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades." @default.
- NCIT_C29375 NCIT_A32 NCIT_C1909 @default.
- NCIT_C29375 NCIT_A6 NCIT_C62070 @default.
- NCIT_C29375 NCIT_A7 NCIT_C54701 @default.
- NCIT_C29375 NCIT_NHC0 "C29375" @default.
- NCIT_C29375 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29375 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29375 NCIT_P107 "Pravastatin Sodium" @default.
- NCIT_C29375 NCIT_P108 "Pravastatin Sodium" @default.
- NCIT_C29375 NCIT_P207 "C0700474" @default.
- NCIT_C29375 NCIT_P210 "81131-70-6" @default.
- NCIT_C29375 NCIT_P319 "3M8608UQ61" @default.
- NCIT_C29375 NCIT_P322 "CTRP" @default.
- NCIT_C29375 NCIT_P322 "FDA" @default.
- NCIT_C29375 NCIT_P322 "GDC" @default.
- NCIT_C29375 NCIT_P325 "A drug used to lower the amount of cholesterol in the blood and to prevent stroke and heart attack. It is also being studied in the treatment of cancer and other conditions. Pravastatin sodium blocks an enzyme that helps make cholesterol in the body. It may also make tumor cells more sensitive to anticancer drugs. It is a type of HMG-CoA reductase inhibitor, a type of statin, and a type of chemosensitizer." @default.
- NCIT_C29375 NCIT_P329 "424450" @default.
- NCIT_C29375 NCIT_P330 "424450" @default.
- NCIT_C29375 NCIT_P350 "C23H35O7.Na" @default.
- NCIT_C29375 NCIT_P366 "Pravastatin" @default.
- NCIT_C29375 NCIT_P368 "CHEBI:8361" @default.
- NCIT_C29375 NCIT_P375 "Pravastatin Sodium" @default.
- NCIT_C29375 NCIT_P399 "424450" @default.
- NCIT_C29375 normalizedInformationContent "100" @default.
- NCIT_C29375 referenceCount "1" @default.
- NCIT_C29375 hasExactSynonym "PRAVASTATIN SODIUM" @default.
- NCIT_C29375 hasExactSynonym "Pravachol" @default.
- NCIT_C29375 hasExactSynonym "Pravastatin Sodium" @default.
- NCIT_C29375 hasExactSynonym "pravastatin sodium" @default.
- NCIT_C29375 inSubset NCIT_C116977 @default.
- NCIT_C29375 inSubset NCIT_C116978 @default.
- NCIT_C29375 inSubset NCIT_C128784 @default.
- NCIT_C29375 inSubset NCIT_C157711 @default.
- NCIT_C29375 inSubset NCIT_C157712 @default.
- NCIT_C29375 inSubset NCIT_C176424 @default.
- NCIT_C29375 inSubset NCIT_C177537 @default.
- NCIT_C29375 inSubset NCIT_C63923 @default.
- NCIT_C29375 type Class @default.
- NCIT_C29375 isDefinedBy ncit.owl @default.
- NCIT_C29375 label "Pravastatin Sodium" @default.
- NCIT_C29375 subClassOf NCIT_C1655 @default.
- NCIT_C29375 subClassOf NCIT_C1908 @default.
- NCIT_C29375 subClassOf NCIT_C1909 @default.
- NCIT_C29375 subClassOf NCIT_C29375 @default.
- NCIT_C29375 subClassOf NCIT_C29703 @default.
- NCIT_C29375 subClassOf NCIT_C471 @default.
- NCIT_C29375 subClassOf NCIT_C78276 @default.