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- NCIT_C29383 IAO_0000115 "The bromide salt form of propantheline, a quaternary ammonium compound structurally related to belladonna alkaloids. Propantheline bromide competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. An aspartic acid residue present in the N-terminal portion of the third trans-membrane helix of the muscarinic receptor is believed to form an ionic bond with the tertiary or quaternary nitrogen of the antagonist. Antagonism leads to a reduction of exocrine glands secretions and to relax bronchial muscle and reduce tone and motility of intestinal smooth muscle." @default.
- NCIT_C29383 NCIT_A6 NCIT_C78077 @default.
- NCIT_C29383 NCIT_NHC0 "C29383" @default.
- NCIT_C29383 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29383 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29383 NCIT_P108 "Propantheline Bromide" @default.
- NCIT_C29383 NCIT_P207 "C0033448" @default.
- NCIT_C29383 NCIT_P210 "50-34-0" @default.
- NCIT_C29383 NCIT_P319 "UX9Z118X9F" @default.
- NCIT_C29383 NCIT_P322 "FDA" @default.
- NCIT_C29383 NCIT_P350 "C23H30NO3.Br" @default.
- NCIT_C29383 NCIT_P366 "Propantheline_Bromide" @default.
- NCIT_C29383 normalizedInformationContent "100" @default.
- NCIT_C29383 referenceCount "1" @default.
- NCIT_C29383 hasExactSynonym "PROPANTHELINE BROMIDE" @default.
- NCIT_C29383 hasExactSynonym "Pro-banthine" @default.
- NCIT_C29383 hasExactSynonym "Propantheline Bromide" @default.
- NCIT_C29383 inSubset NCIT_C63923 @default.
- NCIT_C29383 type Class @default.
- NCIT_C29383 isDefinedBy ncit.owl @default.
- NCIT_C29383 label "Propantheline Bromide" @default.
- NCIT_C29383 subClassOf NCIT_C1908 @default.
- NCIT_C29383 subClassOf NCIT_C1909 @default.
- NCIT_C29383 subClassOf NCIT_C29383 @default.
- NCIT_C29383 subClassOf NCIT_C29704 @default.
- NCIT_C29383 subClassOf NCIT_C66880 @default.
- NCIT_C29383 subClassOf NCIT_C78272 @default.