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- NCIT_C29385 IAO_0000115 "The hydrochloride salt form of the d-isomer of synthetic diphenyl propionate derivative propoxyphene, with narcotic analgesic effect. This agent mimics the effects of the endogenous opiate dextropropoxyphene, by binding to mu receptors located throughout the central nervous system. The binding results in GTP to GDP exchanges on the mu-G-protein complex, by which effector adenylate cyclase is inactivated thereby decreasing intracellular cAMP. This, in turn, inhibits the release of various nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, noradrenaline, vasopressin, and somatostatin. In addition, dextropropoxyphene closes N-type voltage-gated calcium channels and opens calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization, thereby reducing neuronal excitability, which further decreases the perception of pain." @default.
- NCIT_C29385 NCIT_A6 NCIT_C61912 @default.
- NCIT_C29385 NCIT_NHC0 "C29385" @default.
- NCIT_C29385 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29385 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29385 NCIT_P108 "Propoxyphene Hydrochloride" @default.
- NCIT_C29385 NCIT_P208 "CL449034" @default.
- NCIT_C29385 NCIT_P210 "1639-60-7" @default.
- NCIT_C29385 NCIT_P302 "extravasation resulting from intravenous anthracycline chemotherapy." @default.
- NCIT_C29385 NCIT_P319 "CB2TL9PS0T" @default.
- NCIT_C29385 NCIT_P322 "FDA" @default.
- NCIT_C29385 NCIT_P329 "508976" @default.
- NCIT_C29385 NCIT_P330 "508976" @default.
- NCIT_C29385 NCIT_P350 "C22H29NO2.HCl" @default.
- NCIT_C29385 NCIT_P366 "Propoxyphene_Hydrochloride" @default.
- NCIT_C29385 NCIT_P368 "CHEBI:8498" @default.
- NCIT_C29385 NCIT_P399 "508976" @default.
- NCIT_C29385 normalizedInformationContent "100" @default.
- NCIT_C29385 referenceCount "1" @default.
- NCIT_C29385 hasExactSynonym "Dextropropoxyphene Hydrochloride" @default.
- NCIT_C29385 hasExactSynonym "Dolene" @default.
- NCIT_C29385 hasExactSynonym "Dolotard" @default.
- NCIT_C29385 hasExactSynonym "Doloxene" @default.
- NCIT_C29385 hasExactSynonym "Doraphen" @default.
- NCIT_C29385 hasExactSynonym "PROPOXYPHENE HYDROCHLORIDE" @default.
- NCIT_C29385 hasExactSynonym "Propoxyphene Hydrochloride" @default.
- NCIT_C29385 hasExactSynonym "SK 65" @default.
- NCIT_C29385 hasExactSynonym "Zideron" @default.
- NCIT_C29385 hasExactSynonym "alpha-d-Propoxyphene Hydrochloride" @default.
- NCIT_C29385 hasExactSynonym "d-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol Propionate Hydrochloride" @default.
- NCIT_C29385 inSubset NCIT_C176424 @default.
- NCIT_C29385 inSubset NCIT_C63923 @default.
- NCIT_C29385 type Class @default.
- NCIT_C29385 isDefinedBy ncit.owl @default.
- NCIT_C29385 label "Propoxyphene Hydrochloride" @default.
- NCIT_C29385 subClassOf NCIT_C1908 @default.
- NCIT_C29385 subClassOf NCIT_C1909 @default.
- NCIT_C29385 subClassOf NCIT_C29385 @default.
- NCIT_C29385 subClassOf NCIT_C67413 @default.
- NCIT_C29385 subClassOf NCIT_C78272 @default.