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- NCIT_C29398 IAO_0000115 "The hydrochloride salt form of quinapril, a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Quinapril is hydrolized into its active form quinaprilat, which binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. Quinapril also causes a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels." @default.
- NCIT_C29398 NCIT_A6 NCIT_C62074 @default.
- NCIT_C29398 NCIT_NHC0 "C29398" @default.
- NCIT_C29398 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29398 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29398 NCIT_P108 "Quinapril Hydrochloride" @default.
- NCIT_C29398 NCIT_P207 "C0770920" @default.
- NCIT_C29398 NCIT_P210 "82586-55-8" @default.
- NCIT_C29398 NCIT_P319 "33067B3N2M" @default.
- NCIT_C29398 NCIT_P322 "FDA" @default.
- NCIT_C29398 NCIT_P350 "C25H30N2O5.HCl" @default.
- NCIT_C29398 NCIT_P366 "Quinapril" @default.
- NCIT_C29398 NCIT_P368 "CHEBI:8714" @default.
- NCIT_C29398 normalizedInformationContent "100" @default.
- NCIT_C29398 referenceCount "1" @default.
- NCIT_C29398 hasExactSynonym "Accuprill" @default.
- NCIT_C29398 hasExactSynonym "QUINAPRIL HYDROCHLORIDE" @default.
- NCIT_C29398 hasExactSynonym "Quinapril Hydrochloride" @default.
- NCIT_C29398 inSubset NCIT_C63923 @default.
- NCIT_C29398 type Class @default.
- NCIT_C29398 isDefinedBy ncit.owl @default.
- NCIT_C29398 label "Quinapril Hydrochloride" @default.
- NCIT_C29398 subClassOf NCIT_C1908 @default.
- NCIT_C29398 subClassOf NCIT_C1909 @default.
- NCIT_C29398 subClassOf NCIT_C247 @default.
- NCIT_C29398 subClassOf NCIT_C270 @default.
- NCIT_C29398 subClassOf NCIT_C29398 @default.
- NCIT_C29398 subClassOf NCIT_C471 @default.
- NCIT_C29398 subClassOf NCIT_C78274 @default.
- NCIT_C29398 subClassOf NCIT_C783 @default.