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- NCIT_C29410 IAO_0000115 "An alpha-pyridylmethylsulfinyl benzimidazole and a selective and irreversible proton pump inhibitor with antisecretory property. Rabeprazole enters the parietal cell and accumulates in the acidic secretory canaliculi where the agent is activated by a proton-catalyzed process that results in the formation of a thiophilic sulfonamide or sulfenic acid. The activated rabeprazole forms covalent bonds with the sulfhydryl amino acids cysteine on the extracellular domain of the proton pump (H+/K+ ATPase) at the secretory surface, thereby inhibiting the transport of hydrogen ions, via exchange with potassium ions, into the gastric lumen. Binding to cysteine 813, in particular, is essential for inhibition of gastric acid production." @default.
- NCIT_C29410 NCIT_A5 NCIT_C80692 @default.
- NCIT_C29410 NCIT_NHC0 "C29410" @default.
- NCIT_C29410 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29410 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29410 NCIT_P108 "Rabeprazole" @default.
- NCIT_C29410 NCIT_P207 "C0378482" @default.
- NCIT_C29410 NCIT_P210 "117976-89-3" @default.
- NCIT_C29410 NCIT_P319 "32828355LL" @default.
- NCIT_C29410 NCIT_P322 "FDA" @default.
- NCIT_C29410 NCIT_P329 "641009" @default.
- NCIT_C29410 NCIT_P330 "641009" @default.
- NCIT_C29410 NCIT_P350 "C18H21N3O3S" @default.
- NCIT_C29410 NCIT_P366 "Rabeprazole" @default.
- NCIT_C29410 NCIT_P368 "CHEBI:8768" @default.
- NCIT_C29410 NCIT_P399 "641009" @default.
- NCIT_C29410 normalizedInformationContent "100" @default.
- NCIT_C29410 referenceCount "1" @default.
- NCIT_C29410 hasExactSynonym "2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole" @default.
- NCIT_C29410 hasExactSynonym "LY307640" @default.
- NCIT_C29410 hasExactSynonym "RABEPRAZOLE" @default.
- NCIT_C29410 hasExactSynonym "Rabeprazole" @default.
- NCIT_C29410 inSubset NCIT_C176424 @default.
- NCIT_C29410 inSubset NCIT_C63923 @default.
- NCIT_C29410 type Class @default.
- NCIT_C29410 isDefinedBy ncit.owl @default.
- NCIT_C29410 label "Rabeprazole" @default.
- NCIT_C29410 subClassOf NCIT_C1908 @default.
- NCIT_C29410 subClassOf NCIT_C1909 @default.
- NCIT_C29410 subClassOf NCIT_C29410 @default.
- NCIT_C29410 subClassOf NCIT_C29701 @default.
- NCIT_C29410 subClassOf NCIT_C29723 @default.
- NCIT_C29410 subClassOf NCIT_C78276 @default.