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- NCIT_C29411 IAO_0000115 "A prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis." @default.
- NCIT_C29411 NCIT_A7 NCIT_C91297 @default.
- NCIT_C29411 NCIT_NHC0 "C29411" @default.
- NCIT_C29411 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29411 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29411 NCIT_P107 "Ramipril" @default.
- NCIT_C29411 NCIT_P108 "Ramipril" @default.
- NCIT_C29411 NCIT_P207 "C0072973" @default.
- NCIT_C29411 NCIT_P210 "87333-19-5" @default.
- NCIT_C29411 NCIT_P319 "L35JN3I7SJ" @default.
- NCIT_C29411 NCIT_P322 "CTRP" @default.
- NCIT_C29411 NCIT_P322 "FDA" @default.
- NCIT_C29411 NCIT_P329 "686948" @default.
- NCIT_C29411 NCIT_P330 "686948" @default.
- NCIT_C29411 NCIT_P350 "C23H32N2O5" @default.
- NCIT_C29411 NCIT_P366 "Ramipril" @default.
- NCIT_C29411 NCIT_P368 "CHEBI:8774" @default.
- NCIT_C29411 NCIT_P399 "686948" @default.
- NCIT_C29411 normalizedInformationContent "100" @default.
- NCIT_C29411 referenceCount "1" @default.
- NCIT_C29411 hasExactSynonym "Altace" @default.
- NCIT_C29411 hasExactSynonym "RAMIPRIL" @default.
- NCIT_C29411 hasExactSynonym "Ramipril" @default.
- NCIT_C29411 inSubset NCIT_C116977 @default.
- NCIT_C29411 inSubset NCIT_C116978 @default.
- NCIT_C29411 inSubset NCIT_C173381 @default.
- NCIT_C29411 inSubset NCIT_C173383 @default.
- NCIT_C29411 inSubset NCIT_C176424 @default.
- NCIT_C29411 inSubset NCIT_C63923 @default.
- NCIT_C29411 type Class @default.
- NCIT_C29411 isDefinedBy ncit.owl @default.
- NCIT_C29411 label "Ramipril" @default.
- NCIT_C29411 subClassOf NCIT_C1908 @default.
- NCIT_C29411 subClassOf NCIT_C1909 @default.
- NCIT_C29411 subClassOf NCIT_C247 @default.
- NCIT_C29411 subClassOf NCIT_C270 @default.
- NCIT_C29411 subClassOf NCIT_C29411 @default.
- NCIT_C29411 subClassOf NCIT_C471 @default.
- NCIT_C29411 subClassOf NCIT_C78274 @default.
- NCIT_C29411 subClassOf NCIT_C783 @default.