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- NCIT_C29435 IAO_0000115 "A sequence-selective pyrrolobenzodiazepine (PBD) dimer with potential antineoplastic activity. Following intravenous administration, DNA minor groove binding agent SG2000 preferentially and covalently binds to purine-GATC-pyrimidine sequences, with the imine/carbinolamine moieties of SG2000 binding to the N2 positions of guanines on opposite strands of DNA. This induces interstrand cross-links and inhibits both DNA replication and gene transcription, which lead to the inhibition of cell growth. With a preference for binding to purine-GATC-pyrimidine sequences, SG2000 adducts do not appear to be susceptible to p53-mediated DNA excision repair." @default.
- NCIT_C29435 NCIT_A32 NCIT_C1909 @default.
- NCIT_C29435 NCIT_A7 NCIT_C449 @default.
- NCIT_C29435 NCIT_NHC0 "C29435" @default.
- NCIT_C29435 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29435 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29435 NCIT_P107 "DNA Minor Groove Binding Agent SG2000" @default.
- NCIT_C29435 NCIT_P108 "DNA Minor Groove Binding Agent SG2000" @default.
- NCIT_C29435 NCIT_P175 "694501" @default.
- NCIT_C29435 NCIT_P207 "C1519143" @default.
- NCIT_C29435 NCIT_P210 "232931-57-6" @default.
- NCIT_C29435 NCIT_P319 "KT0ZQ64X1A" @default.
- NCIT_C29435 NCIT_P322 "CTRP" @default.
- NCIT_C29435 NCIT_P322 "FDA" @default.
- NCIT_C29435 NCIT_P322 "GDC" @default.
- NCIT_C29435 NCIT_P325 "A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called DNA cross-linking agents." @default.
- NCIT_C29435 NCIT_P329 "415963" @default.
- NCIT_C29435 NCIT_P330 "415963" @default.
- NCIT_C29435 NCIT_P366 "SJG-136" @default.
- NCIT_C29435 NCIT_P375 "DNA Minor Groove Binding Agent SG2000" @default.
- NCIT_C29435 NCIT_P399 "415963" @default.
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- NCIT_C29435 normalizedInformationContent "100" @default.
- NCIT_C29435 referenceCount "1" @default.
- NCIT_C29435 hasExactSynonym "(11aS,11a'S)-8,8'-(propane-1,3-diylbis(oxy))bis(7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one)" @default.
- NCIT_C29435 hasExactSynonym "BN2629" @default.
- NCIT_C29435 hasExactSynonym "DNA Minor Groove Binding Agent SG2000" @default.
- NCIT_C29435 hasExactSynonym "NSC 694501" @default.
- NCIT_C29435 hasExactSynonym "Pyrrolobenzodiazepine Dimer" @default.
- NCIT_C29435 hasExactSynonym "SG2000" @default.
- NCIT_C29435 hasExactSynonym "SJG-136" @default.
- NCIT_C29435 hasExactSynonym "SJG136" @default.
- NCIT_C29435 inSubset NCIT_C116977 @default.
- NCIT_C29435 inSubset NCIT_C116978 @default.
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- NCIT_C29435 inSubset NCIT_C63923 @default.
- NCIT_C29435 type Class @default.
- NCIT_C29435 isDefinedBy ncit.owl @default.
- NCIT_C29435 label "DNA Minor Groove Binding Agent SG2000" @default.
- NCIT_C29435 subClassOf B177e319502330473ea0814c8900ba420 @default.
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- NCIT_C29435 subClassOf NCIT_C186664 @default.
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- NCIT_C29435 subClassOf NCIT_C2115 @default.
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- NCIT_C29435 subClassOf NCIT_C29435 @default.