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- NCIT_C29454 IAO_0000115 "A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)" @default.
- NCIT_C29454 NCIT_A7 NCIT_C54701 @default.
- NCIT_C29454 NCIT_NHC0 "C29454" @default.
- NCIT_C29454 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29454 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29454 NCIT_P107 "Simvastatin" @default.
- NCIT_C29454 NCIT_P108 "Simvastatin" @default.
- NCIT_C29454 NCIT_P175 "633782" @default.
- NCIT_C29454 NCIT_P207 "C0074554" @default.
- NCIT_C29454 NCIT_P210 "79902-63-9" @default.
- NCIT_C29454 NCIT_P319 "AGG2FN16EV" @default.
- NCIT_C29454 NCIT_P322 "CTRP" @default.
- NCIT_C29454 NCIT_P322 "FDA" @default.
- NCIT_C29454 NCIT_P329 "455226" @default.
- NCIT_C29454 NCIT_P330 "455226" @default.
- NCIT_C29454 NCIT_P350 "C25H38O5" @default.
- NCIT_C29454 NCIT_P366 "Simvastatin" @default.
- NCIT_C29454 NCIT_P368 "CHEBI:9150" @default.
- NCIT_C29454 NCIT_P399 "455226" @default.
- NCIT_C29454 NCIT_R122 NCIT_C16484 @default.
- NCIT_C29454 NCIT_R122 NCIT_C16486 @default.
- NCIT_C29454 NCIT_R122 NCIT_C16554 @default.
- NCIT_C29454 NCIT_R122 NCIT_C16865 @default.
- NCIT_C29454 NCIT_R122 NCIT_C16946 @default.
- NCIT_C29454 NCIT_R122 NCIT_C17021 @default.
- NCIT_C29454 NCIT_R122 NCIT_C17573 @default.
- NCIT_C29454 NCIT_R122 NCIT_C20027 @default.
- NCIT_C29454 NCIT_R122 NCIT_C26548 @default.
- NCIT_C29454 NCIT_R122 NCIT_C28459 @default.
- NCIT_C29454 NCIT_R122 NCIT_C45999 @default.
- NCIT_C29454 NCIT_R122 NCIT_C46000 @default.
- NCIT_C29454 normalizedInformationContent "100" @default.
- NCIT_C29454 referenceCount "1" @default.
- NCIT_C29454 hasExactSynonym "MK 733" @default.
- NCIT_C29454 hasExactSynonym "SIMVASTATIN" @default.
- NCIT_C29454 hasExactSynonym "Simvastatin" @default.
- NCIT_C29454 hasExactSynonym "Synvinolin" @default.
- NCIT_C29454 hasExactSynonym "Zocor" @default.
- NCIT_C29454 hasExactSynonym "[1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2,2-dimethylbutanoate" @default.
- NCIT_C29454 inSubset NCIT_C116977 @default.
- NCIT_C29454 inSubset NCIT_C116978 @default.
- NCIT_C29454 inSubset NCIT_C173381 @default.
- NCIT_C29454 inSubset NCIT_C173383 @default.
- NCIT_C29454 inSubset NCIT_C176424 @default.
- NCIT_C29454 inSubset NCIT_C63923 @default.
- NCIT_C29454 type Class @default.
- NCIT_C29454 isDefinedBy ncit.owl @default.
- NCIT_C29454 label "Simvastatin" @default.
- NCIT_C29454 subClassOf B23c96624a20c3fa7c04ea7da4e229550 @default.
- NCIT_C29454 subClassOf B2cb5b26136309b6b4113c32de3130fea @default.
- NCIT_C29454 subClassOf B49948cf5fbb2dc66c2b84dfe84c584e3 @default.
- NCIT_C29454 subClassOf B569853a19f5da33bba4ab00eb8c532cb @default.
- NCIT_C29454 subClassOf B62045ef34c6b843ba273e6511163d073 @default.
- NCIT_C29454 subClassOf B88f7105051eda35f398aff681436c657 @default.
- NCIT_C29454 subClassOf NCIT_C1655 @default.
- NCIT_C29454 subClassOf NCIT_C1908 @default.
- NCIT_C29454 subClassOf NCIT_C1909 @default.
- NCIT_C29454 subClassOf NCIT_C29454 @default.
- NCIT_C29454 subClassOf NCIT_C29703 @default.
- NCIT_C29454 subClassOf NCIT_C471 @default.
- NCIT_C29454 subClassOf NCIT_C78276 @default.