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- NCIT_C29470 IAO_0000115 "The succinate salt form of sumatriptan, a member of the triptan class of compounds with anti-migraine property. Sumatriptan succinate selectively binds to and activates serotonin 5-HT1 receptors. This results in constriction of meningeal, dural, cerebral or pial blood vessels via stimulation of the 5-HT1B receptors, thereby reducing the vascular pulsation and may provide relief in migraine headaches. Furthermore, agonistic action of this agent through presynaptic stimulation of 5-HT1D and/or 5-HT1F receptors prevents release of vasoactive and pro-inflammatory neuropeptide (calcitonin gene-related peptide), thereby may also relieve migraine headaches. In addition, central inhibition of pain transmission via the inhibition of trigeminal neurons in the brain stems and upper spinal cord mediated by 5-HT1B, 5-HT1D or 5-HT 1F receptors also aides in the alleviation of migraine pain." @default.
- NCIT_C29470 NCIT_A6 NCIT_C1240 @default.
- NCIT_C29470 NCIT_NHC0 "C29470" @default.
- NCIT_C29470 NCIT_P106 "Organic Chemical" @default.
- NCIT_C29470 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29470 NCIT_P108 "Sumatriptan Succinate" @default.
- NCIT_C29470 NCIT_P207 "C0206599" @default.
- NCIT_C29470 NCIT_P210 "103628-48-4" @default.
- NCIT_C29470 NCIT_P319 "J8BDZ68989" @default.
- NCIT_C29470 NCIT_P322 "FDA" @default.
- NCIT_C29470 NCIT_P329 "779006" @default.
- NCIT_C29470 NCIT_P330 "779006" @default.
- NCIT_C29470 NCIT_P350 "C14H21N3O2S.C4H6O4" @default.
- NCIT_C29470 NCIT_P366 "Sumatriptan_Succinate" @default.
- NCIT_C29470 NCIT_P368 "CHEBI:64359" @default.
- NCIT_C29470 NCIT_P399 "779006" @default.
- NCIT_C29470 normalizedInformationContent "100" @default.
- NCIT_C29470 referenceCount "1" @default.
- NCIT_C29470 hasExactSynonym "Imitrex" @default.
- NCIT_C29470 hasExactSynonym "SUMATRIPTAN SUCCINATE" @default.
- NCIT_C29470 hasExactSynonym "Sumatriptan Succinate" @default.
- NCIT_C29470 inSubset NCIT_C176424 @default.
- NCIT_C29470 inSubset NCIT_C63923 @default.
- NCIT_C29470 type Class @default.
- NCIT_C29470 isDefinedBy ncit.owl @default.
- NCIT_C29470 label "Sumatriptan Succinate" @default.
- NCIT_C29470 subClassOf NCIT_C1908 @default.
- NCIT_C29470 subClassOf NCIT_C1909 @default.
- NCIT_C29470 subClassOf NCIT_C29470 @default.
- NCIT_C29470 subClassOf NCIT_C47794 @default.
- NCIT_C29470 subClassOf NCIT_C78272 @default.