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- NCIT_C29501 IAO_0000115 "The maleate salt form of timolol, a propanolamine derivative and a non-selective beta-adrenergic antagonist with antihypertensive property. Timolol competitively binds to beta-1-adrenergic receptors in the heart and vascular smooth muscle and beta-2-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in beta-adrenergic stimulation. Beta-1-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta-2-blockade results in an increase in peripheral vascular resistance. The ultimate results include vasodilation, and negative chronotropic and inotropic effects. In addition, timolol reduces intra-ocular pressure possibly by decreasing aqueous humor production by reduction of blood flow to the ciliary processes and cAMP synthesis." @default.
- NCIT_C29501 NCIT_A6 NCIT_C47757 @default.
- NCIT_C29501 NCIT_NHC0 "C29501" @default.
- NCIT_C29501 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29501 NCIT_P108 "Timolol Maleate" @default.
- NCIT_C29501 NCIT_P207 "C0087093" @default.
- NCIT_C29501 NCIT_P210 "26921-17-5" @default.
- NCIT_C29501 NCIT_P319 "P8Y54F701R" @default.
- NCIT_C29501 NCIT_P322 "FDA" @default.
- NCIT_C29501 NCIT_P329 "803210" @default.
- NCIT_C29501 NCIT_P330 "803210" @default.
- NCIT_C29501 NCIT_P350 "C13H24N4O3S.C4H4O4" @default.
- NCIT_C29501 NCIT_P366 "Timolol_Maleate" @default.
- NCIT_C29501 NCIT_P368 "CHEBI:9600" @default.
- NCIT_C29501 NCIT_P399 "803210" @default.
- NCIT_C29501 NCIT_R122 NCIT_C16484 @default.
- NCIT_C29501 NCIT_R122 NCIT_C16486 @default.
- NCIT_C29501 NCIT_R122 NCIT_C16554 @default.
- NCIT_C29501 NCIT_R122 NCIT_C16865 @default.
- NCIT_C29501 NCIT_R122 NCIT_C16946 @default.
- NCIT_C29501 NCIT_R122 NCIT_C17021 @default.
- NCIT_C29501 NCIT_R122 NCIT_C17287 @default.
- NCIT_C29501 NCIT_R122 NCIT_C20027 @default.
- NCIT_C29501 NCIT_R122 NCIT_C26548 @default.
- NCIT_C29501 NCIT_R122 NCIT_C28459 @default.
- NCIT_C29501 normalizedInformationContent "100" @default.
- NCIT_C29501 referenceCount "1" @default.
- NCIT_C29501 hasExactSynonym "TIMOLOL MALEATE" @default.
- NCIT_C29501 hasExactSynonym "Timolol Maleate" @default.
- NCIT_C29501 hasExactSynonym "Timolol maleate" @default.
- NCIT_C29501 inSubset NCIT_C176424 @default.
- NCIT_C29501 inSubset NCIT_C63923 @default.
- NCIT_C29501 type Class @default.
- NCIT_C29501 isDefinedBy ncit.owl @default.
- NCIT_C29501 label "Timolol Maleate" @default.
- NCIT_C29501 subClassOf B3b30df9ed88cbeb3a735f3c93853ba06 @default.
- NCIT_C29501 subClassOf B440b4be563f8382affb01e3c18301b34 @default.
- NCIT_C29501 subClassOf NCIT_C1908 @default.
- NCIT_C29501 subClassOf NCIT_C1909 @default.
- NCIT_C29501 subClassOf NCIT_C29501 @default.
- NCIT_C29501 subClassOf NCIT_C29576 @default.
- NCIT_C29501 subClassOf NCIT_C29747 @default.
- NCIT_C29501 subClassOf NCIT_C72900 @default.
- NCIT_C29501 subClassOf NCIT_C78272 @default.