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- NCIT_C29519 IAO_0000115 "A pteridine derivative with potassium-sparing diuretic property. Triamterene blocks the sodium-potassium exchange pump (Na-K-ATPase) in the luminal membrane of principal cells in the late distal tubule, cortical collecting tubule and collecting duct in the kidney. This reversible inhibition of the electrogenic sodium transport decreases the lumen-negative transepithelial potential difference and thus reduces the driving force for K+ movement into the tubular lumen resulting in the inhibition of sodium reabsorption in exchange for K+ and H+." @default.
- NCIT_C29519 NCIT_NHC0 "C29519" @default.
- NCIT_C29519 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29519 NCIT_P108 "Triamterene" @default.
- NCIT_C29519 NCIT_P175 "639359" @default.
- NCIT_C29519 NCIT_P175 "77625" @default.
- NCIT_C29519 NCIT_P207 "C0040869" @default.
- NCIT_C29519 NCIT_P210 "396-01-0" @default.
- NCIT_C29519 NCIT_P319 "WS821Z52LQ" @default.
- NCIT_C29519 NCIT_P322 "FDA" @default.
- NCIT_C29519 NCIT_P350 "C12H11N7" @default.
- NCIT_C29519 NCIT_P366 "Triamterene" @default.
- NCIT_C29519 normalizedInformationContent "100" @default.
- NCIT_C29519 referenceCount "1" @default.
- NCIT_C29519 hasExactSynonym "6-Phenyl-2,4,7-pteridinetriamine" @default.
- NCIT_C29519 hasExactSynonym "6-Phenyl-2,4,7-triaminopteridine" @default.
- NCIT_C29519 hasExactSynonym "Dyrenium" @default.
- NCIT_C29519 hasExactSynonym "TRIAMTERENE" @default.
- NCIT_C29519 hasExactSynonym "Triamterene" @default.
- NCIT_C29519 inSubset NCIT_C63923 @default.
- NCIT_C29519 type Class @default.
- NCIT_C29519 isDefinedBy ncit.owl @default.
- NCIT_C29519 label "Triamterene" @default.
- NCIT_C29519 subClassOf NCIT_C1908 @default.
- NCIT_C29519 subClassOf NCIT_C1909 @default.
- NCIT_C29519 subClassOf NCIT_C29519 @default.
- NCIT_C29519 subClassOf NCIT_C448 @default.
- NCIT_C29519 subClassOf NCIT_C49186 @default.
- NCIT_C29519 subClassOf NCIT_C78275 @default.