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- NCIT_C29539 IAO_0000115 "A combination preparation of a synthetic angiotensin-converting enzyme (ACE) inhibitor prodrug and a diuretic thiazide, with antihypertensive activity. Enalapril maleate is de-esterified within the cells into its active form enalaprilat that inhibits ACE, thereby prevents the formation of angiotensin II, and blocks angiotensin II mediated activities, including vasoconstriction and stimulation of aldosterone synthesis and secretion, which regulates extracellular sodium concentration. Hydrochlorothiazide inhibits electrolytes reabsorption via binding to Na-Cl cotransporter on the renal distal tubular, thereby increasing excretion of sodium, potassium, chloride, bicarbonate and water. Both agents lead to a reduction in blood pressure." @default.
- NCIT_C29539 NCIT_NHC0 "C29539" @default.
- NCIT_C29539 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29539 NCIT_P108 "Enalapril Maleate/Hydrochlorothiazide" @default.
- NCIT_C29539 NCIT_P207 "C0633761" @default.
- NCIT_C29539 NCIT_P366 "Enalapril_Maleate-Hydrochlorothiazide" @default.
- NCIT_C29539 normalizedInformationContent "100" @default.
- NCIT_C29539 referenceCount "1" @default.
- NCIT_C29539 hasExactSynonym "Enalapril Maleate/Hydrochlorothiazide" @default.
- NCIT_C29539 hasExactSynonym "Vaseretic" @default.
- NCIT_C29539 type Class @default.
- NCIT_C29539 isDefinedBy ncit.owl @default.
- NCIT_C29539 label "Enalapril Maleate/Hydrochlorothiazide" @default.
- NCIT_C29539 subClassOf NCIT_C1908 @default.
- NCIT_C29539 subClassOf NCIT_C1909 @default.
- NCIT_C29539 subClassOf NCIT_C29539 @default.
- NCIT_C29539 subClassOf NCIT_C29629 @default.
- NCIT_C29539 subClassOf NCIT_C29636 @default.