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- NCIT_C29548 IAO_0000115 "Wild Type and Mutant MGMT Vectors are genetic carrier vehicles containing an in vivo selection marker derived from natural or mutant O-6 methylguanine-DNA methyltransferase (MGMT) and are used in gene therapy and biomedical research for selection of specific traits in targeted cells, such as genes that confer resistance to chemotherapeutic agents. Mutant MGMTs resistant to the MGMT inactivator O-6-benzylguanine (BG) are potent markers for in vivo selection in irradiated and non-myelo ablated mouse models using BG plus alkylating agents to drive selection. (NCI04)" @default.
- NCIT_C29548 NCIT_NHC0 "C29548" @default.
- NCIT_C29548 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29548 NCIT_P108 "Wild Type and Mutant MGMT Vector" @default.
- NCIT_C29548 NCIT_P175 "718736" @default.
- NCIT_C29548 NCIT_P207 "C1520151" @default.
- NCIT_C29548 NCIT_P366 "Wild_Type_and_Mutant_MGMT_Vector" @default.
- NCIT_C29548 normalizedInformationContent "100" @default.
- NCIT_C29548 referenceCount "1" @default.
- NCIT_C29548 hasExactSynonym "Wild Type and Mutant MGMT Vector" @default.
- NCIT_C29548 type Class @default.
- NCIT_C29548 isDefinedBy ncit.owl @default.
- NCIT_C29548 label "Wild Type and Mutant MGMT Vector" @default.
- NCIT_C29548 subClassOf NCIT_C1329 @default.
- NCIT_C29548 subClassOf NCIT_C1908 @default.
- NCIT_C29548 subClassOf NCIT_C1913 @default.
- NCIT_C29548 subClassOf NCIT_C2173 @default.
- NCIT_C29548 subClassOf NCIT_C2463 @default.
- NCIT_C29548 subClassOf NCIT_C29548 @default.
- NCIT_C29548 subClassOf NCIT_C449 @default.
- NCIT_C29548 subClassOf NCIT_C706 @default.
- NCIT_C29548 subClassOf NCIT_C708 @default.
- NCIT_C29548 subClassOf NCIT_C718 @default.