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- NCIT_C29648 IAO_0000115 "Nonsense-Mediated Decay is the widely conserved process in eukaryotes whereby certain alternatively spliced RNAs, some selenoprotein mRNAs, and nonsense or frame-shift mutations that result in premature translation termination signal rapid mRNA degradation; the mechanism that eliminates mRNAs with premature termination codons, reducing the accumulation of deleterious proteins and their effects. NMD is initiated during translation when hUpf proteins phosphorylated by SMG proteins cooperate with an exon-junction complex to identify mRNAs with premature stop codons and mark the transcript for rapid decay. Degrading mRNAs from both ends, NMD involves decapping, deadenylating, and exonucleolytic activities." @default.
- NCIT_C29648 NCIT_NHC0 "C29648" @default.
- NCIT_C29648 NCIT_P106 "Molecular Function" @default.
- NCIT_C29648 NCIT_P108 "Nonsense-Mediated Decay" @default.
- NCIT_C29648 NCIT_P207 "C1158013" @default.
- NCIT_C29648 NCIT_P366 "Nonsense-Mediated_Decay" @default.
- NCIT_C29648 normalizedInformationContent "82.536929774922015" @default.
- NCIT_C29648 referenceCount "14" @default.
- NCIT_C29648 hasExactSynonym "NMD" @default.
- NCIT_C29648 hasExactSynonym "Nonsense-Mediated Decay" @default.
- NCIT_C29648 hasExactSynonym "Nonsense-Mediated mRNA Decay" @default.
- NCIT_C29648 type Class @default.
- NCIT_C29648 isDefinedBy ncit.owl @default.
- NCIT_C29648 label "Nonsense-Mediated Decay" @default.
- NCIT_C29648 subClassOf NCIT_C17710 @default.
- NCIT_C29648 subClassOf NCIT_C17828 @default.
- NCIT_C29648 subClassOf NCIT_C21049 @default.
- NCIT_C29648 subClassOf NCIT_C28498 @default.
- NCIT_C29648 subClassOf NCIT_C29645 @default.
- NCIT_C29648 subClassOf NCIT_C29648 @default.