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- NCIT_C29854 IAO_0000115 "The active metabolite of sulindac, a sulfinylindene derivative with anti-inflammatory, analgesic and antipyretic properties. Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) which inhibits cyclooxygenase (COX-1 and-2)-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. This agent may possess chemopreventive activity against colorectal tumors through a mechanism that involves the induction of apoptosis. The sulfide metabolite is excreted in the bile and reabsorbed from the intestine, thereby helping to maintain constant blood levels and reduce gastrointestinal side effects. (NCI04)" @default.
- NCIT_C29854 NCIT_NHC0 "C29854" @default.
- NCIT_C29854 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C29854 NCIT_P108 "Sulindac Sulfide" @default.
- NCIT_C29854 NCIT_P207 "C0075615" @default.
- NCIT_C29854 NCIT_P210 "49627-27-2" @default.
- NCIT_C29854 NCIT_P319 "6UVA8S2DEY" @default.
- NCIT_C29854 NCIT_P322 "FDA" @default.
- NCIT_C29854 NCIT_P366 "Sulindac_Sulfide" @default.
- NCIT_C29854 normalizedInformationContent "100" @default.
- NCIT_C29854 referenceCount "1" @default.
- NCIT_C29854 hasExactSynonym "(1Z)-5-Fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic Acid" @default.
- NCIT_C29854 hasExactSynonym "SULINDAC SULFIDE" @default.
- NCIT_C29854 hasExactSynonym "Sulindac Sulfide" @default.
- NCIT_C29854 inSubset NCIT_C63923 @default.
- NCIT_C29854 type Class @default.
- NCIT_C29854 isDefinedBy ncit.owl @default.
- NCIT_C29854 label "Sulindac Sulfide" @default.
- NCIT_C29854 subClassOf NCIT_C1323 @default.
- NCIT_C29854 subClassOf NCIT_C1908 @default.
- NCIT_C29854 subClassOf NCIT_C1909 @default.
- NCIT_C29854 subClassOf NCIT_C2198 @default.
- NCIT_C29854 subClassOf NCIT_C2356 @default.
- NCIT_C29854 subClassOf NCIT_C241 @default.
- NCIT_C29854 subClassOf NCIT_C257 @default.
- NCIT_C29854 subClassOf NCIT_C29854 @default.
- NCIT_C29854 subClassOf NCIT_C471 @default.
- NCIT_C29854 subClassOf NCIT_C78272 @default.