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- NCIT_C29940 IAO_0000115 "Histone-lysine N-methyltransferase SETDB1 (1291 aa, ~143 kDa) is encoded by the human SETDB1 gene. This protein is involved in histone methylation." @default.
- NCIT_C29940 NCIT_NHC0 "C29940" @default.
- NCIT_C29940 NCIT_P100 "604396" @default.
- NCIT_C29940 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C29940 NCIT_P106 "Enzyme" @default.
- NCIT_C29940 NCIT_P108 "Histone-Lysine N-Methyltransferase SETDB1" @default.
- NCIT_C29940 NCIT_P207 "C1122259" @default.
- NCIT_C29940 NCIT_P366 "Histone-H3-K9_Methyltransferase-4" @default.
- NCIT_C29940 NCIT_P93 "Q15047" @default.
- NCIT_C29940 NCIT_P98 "Histone H3-K9 Methyltransferase 4 methylates histone H3 Lys-9 in epigenetic transcriptional repression that recruits HP1 proteins to methylated histones. SETDB1 contains an MBD domain, a pre-SET, a SET, and a post-SET domain, and 2 Tudor domains; pre-SET, SET and post-SET are required for methyltransferase activity. Isoform 2 lacks all methyltransferase domains. The conserved SET domain is implicated in transcriptional modulation of active or repressed chromatin through remodeling. Targeted to histone by TRIM28/TIF1B, SETDB1 contributes to euchromatic gene silencing by KRAB zinc-finger proteins and may interact with ERG." @default.
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- NCIT_C29940 referenceCount "1" @default.
- NCIT_C29940 hasExactSynonym "EC 2.1.1.43" @default.
- NCIT_C29940 hasExactSynonym "ERG-Associated Protein with Set Domain" @default.
- NCIT_C29940 hasExactSynonym "ESET" @default.
- NCIT_C29940 hasExactSynonym "H3-K9-HMTase 4" @default.
- NCIT_C29940 hasExactSynonym "Histone H3-K9 Methyltransferase 4" @default.
- NCIT_C29940 hasExactSynonym "Histone-Lysine N-Methyltransferase H3 Lysine-9 Specific 4" @default.
- NCIT_C29940 hasExactSynonym "Histone-Lysine N-Methyltransferase SETDB1" @default.
- NCIT_C29940 hasExactSynonym "Lysine N-Methyltransferase 1E" @default.
- NCIT_C29940 hasExactSynonym "SET Domain Bifurcated 1" @default.
- NCIT_C29940 hasExactSynonym "SETDB1" @default.
- NCIT_C29940 type Class @default.
- NCIT_C29940 isDefinedBy ncit.owl @default.
- NCIT_C29940 label "Histone-Lysine N-Methyltransferase SETDB1" @default.
- NCIT_C29940 subClassOf NCIT_C16554 @default.
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