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- NCIT_C29970 IAO_0000115 "Ski-like protein (684 aa, ~77 kDa) is encoded by the human SKIL gene. This protein plays a role in the regulation of both gene transcription and signal transduction." @default.
- NCIT_C29970 NCIT_NHC0 "C29970" @default.
- NCIT_C29970 NCIT_P100 "165340" @default.
- NCIT_C29970 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C29970 NCIT_P108 "SKI-Like Protein" @default.
- NCIT_C29970 NCIT_P207 "C1448598" @default.
- NCIT_C29970 NCIT_P366 "SKI-Like_Protein-SKIL" @default.
- NCIT_C29970 NCIT_P93 "P12757" @default.
- NCIT_C29970 NCIT_P98 "Ski-like protein is expressed as alternative isoforms: SNON (684-aa), SNOA (415-aa), SNON2, SNOI (skeletal muscle restricted). SNON interacts with SMAD2/3 and regulates cell growth and cell differentiation signaling. Absent TGFB, SNON binds nuclear SMAD4 and represses target gene promoter activity. APC activator CDH1 forms a complex with SNON, SMAD3, and TGFB-regulated ubiquitin ligase APC, regulating SNON degradation. TGFB activates SMAD2/3/4 nuclear translocation. SNON degradation allows SMAD2/4 to activate TGFB target genes. TGFB also induces SNON expression, which binds to SMAD complexes and shuts off TGFB signaling." @default.
- NCIT_C29970 NCIT_R131 NCIT_C17132 @default.
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- NCIT_C29970 NCIT_R131 NCIT_C91690 @default.
- NCIT_C29970 NCIT_R52 NCIT_C17021 @default.
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- NCIT_C29970 NCIT_R53 NCIT_C18081 @default.
- NCIT_C29970 NCIT_R53 NCIT_C19077 @default.
- NCIT_C29970 NCIT_R53 NCIT_C20480 @default.
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- NCIT_C29970 NCIT_R53 NCIT_C21049 @default.
- NCIT_C29970 NCIT_R53 NCIT_C21050 @default.
- NCIT_C29970 NCIT_R53 NCIT_C28498 @default.
- NCIT_C29970 NCIT_R54 NCIT_C16612 @default.
- NCIT_C29970 NCIT_R54 NCIT_C20194 @default.
- NCIT_C29970 NCIT_R54 NCIT_C20703 @default.
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- NCIT_C29970 NCIT_R54 NCIT_C20921 @default.
- NCIT_C29970 NCIT_R54 NCIT_C24812 @default.
- NCIT_C29970 NCIT_R54 NCIT_C54362 @default.
- NCIT_C29970 normalizedInformationContent "100" @default.
- NCIT_C29970 referenceCount "1" @default.
- NCIT_C29970 hasExactSynonym "SKI-Like Protein SKIL" @default.
- NCIT_C29970 hasExactSynonym "SKI-Like Protein" @default.
- NCIT_C29970 hasExactSynonym "SKI-Like" @default.
- NCIT_C29970 hasExactSynonym "SKI-Related Oncogene SNO Protein" @default.
- NCIT_C29970 hasExactSynonym "SKI-Related Oncogene" @default.
- NCIT_C29970 hasExactSynonym "SKI-Related Protein" @default.
- NCIT_C29970 hasExactSynonym "SKIL" @default.
- NCIT_C29970 hasExactSynonym "SNO" @default.
- NCIT_C29970 hasExactSynonym "SNOA" @default.
- NCIT_C29970 hasExactSynonym "SNON" @default.
- NCIT_C29970 type Class @default.
- NCIT_C29970 isDefinedBy ncit.owl @default.
- NCIT_C29970 label "SKI-Like Protein" @default.
- NCIT_C29970 subClassOf NCIT_C17021 @default.
- NCIT_C29970 subClassOf NCIT_C18466 @default.
- NCIT_C29970 subClassOf NCIT_C18515 @default.
- NCIT_C29970 subClassOf NCIT_C20027 @default.
- NCIT_C29970 subClassOf NCIT_C26199 @default.
- NCIT_C29970 subClassOf NCIT_C26548 @default.
- NCIT_C29970 subClassOf NCIT_C29970 @default.
- NCIT_C29970 equivalentClass Bb393f928aaa0c259690bbada679c25d9 @default.
- NCIT_C29970 equivalentClass Be84c1317baba78d227ad42603e873480 @default.