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- NCIT_C30093 IAO_0000115 "Transcription factor Dp-2 (446 aa, ~49 kDa) is encoded by the human TFDP2 gene. This protein is involved in transcriptional regulation and cell cycle progression." @default.
- NCIT_C30093 NCIT_NHC0 "C30093" @default.
- NCIT_C30093 NCIT_P100 "602160" @default.
- NCIT_C30093 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C30093 NCIT_P108 "Transcription Factor Dp-2" @default.
- NCIT_C30093 NCIT_P207 "C0528328" @default.
- NCIT_C30093 NCIT_P366 "Transcription_Factor-DP2" @default.
- NCIT_C30093 NCIT_P93 "Q14188" @default.
- NCIT_C30093 NCIT_P98 "Expressed in heart, skeletal muscle, placenta, kidney, brain, lung, and liver, human TFDP2 Gene (E2F/DP Family) encodes alternative isoforms alpha (446-aa, 49-kDa), beta (369-aa, 43-kDa), gamma (370-aa), and delta (385-aa, 48-kDa) of phosphorylated nuclear Transcription Factor Dp-2, which in a heterodimeric complex with E2F family members regulates genes required for G1/S cell-cycle progression, S-phase progression, cell cycle regulation, DNA replication, or apoptosis. Interaction of DP/E2F with hypophosphorylated RB1, P107, and P130 inhibits the E2F transactivation domain. In mid-to-late G1, phosphorylated RB detaches from DP/E2F rendering E2F transcriptionally active. Viral oncoproteins E1A, T-antigen, and HPV E7 can sequester RB protein, releasing active DP/E2F complex." @default.
- NCIT_C30093 NCIT_P98 "Transcription factor Dp-1 binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3'. (UniProt)" @default.
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- NCIT_C30093 normalizedInformationContent "100" @default.
- NCIT_C30093 referenceCount "1" @default.
- NCIT_C30093 hasExactSynonym "DRTF1" @default.
- NCIT_C30093 hasExactSynonym "E2F Dimerization Partner 2" @default.
- NCIT_C30093 hasExactSynonym "TFDP2" @default.
- NCIT_C30093 hasExactSynonym "Transcription Factor Dp-2" @default.
- NCIT_C30093 type Class @default.
- NCIT_C30093 isDefinedBy ncit.owl @default.
- NCIT_C30093 label "Transcription Factor Dp-2" @default.
- NCIT_C30093 subClassOf NCIT_C17021 @default.
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