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- NCIT_C30105 IAO_0000115 "Toll-like receptor 4 (839 aa, ~96 kDa) is encoded by the human TLR4 gene. This protein is involved in regulation of both fatty acid-induced inflammation and the innate immune response following bacterial lipopolysaccharide binding." @default.
- NCIT_C30105 NCIT_NHC0 "C30105" @default.
- NCIT_C30105 NCIT_P100 "603030" @default.
- NCIT_C30105 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C30105 NCIT_P106 "Receptor" @default.
- NCIT_C30105 NCIT_P107 "Toll-Like Receptor 4" @default.
- NCIT_C30105 NCIT_P108 "Toll-Like Receptor 4" @default.
- NCIT_C30105 NCIT_P207 "C1321919" @default.
- NCIT_C30105 NCIT_P322 "CTRP" @default.
- NCIT_C30105 NCIT_P366 "Toll-Like_Receptor-4" @default.
- NCIT_C30105 NCIT_P93 "O00206" @default.
- NCIT_C30105 NCIT_P98 "As part of the LPS receptor (with CD14 and LY96), TLR4 mediates the immune response to LPS in gram-negative bacteria. Binding to LY96 via the extracellular domain and to MyD88 and TIRAP via their TIR domains, TLR4 acts via MyD88, TIRAP, and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and the inflammatory response. TLR4 Asn-526 and Asn-575 glycosylation seems necessary for the LPS-response." @default.
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- NCIT_C30105 hasExactSynonym "CD284 Antigen" @default.
- NCIT_C30105 hasExactSynonym "TLR4" @default.
- NCIT_C30105 hasExactSynonym "TOLL" @default.
- NCIT_C30105 hasExactSynonym "Toll Homolog" @default.
- NCIT_C30105 hasExactSynonym "Toll-Like Receptor 4" @default.
- NCIT_C30105 hasExactSynonym "hToll" @default.
- NCIT_C30105 inSubset NCIT_C116977 @default.
- NCIT_C30105 inSubset NCIT_C142799 @default.
- NCIT_C30105 inSubset NCIT_C142800 @default.
- NCIT_C30105 type Class @default.
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