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- NCIT_C317 IAO_0000115 "The mesylate salt of bromocriptine, a semisynthetic ergot alkaloid with dopaminergic, antidyskinetic, and antiprolactinemic activities. Bromocriptine selectively binds to and activates postsynaptic dopamine D2 receptors in the corpus striatum of the central nervous system (CNS). Activation of these D2 receptors activate inhibitory G-proteins, which inhibit adenylyl cyclase, preventing signal transduction mediated via cAMP and resulting in the inhibition of neurotransmission and an antidyskinetic effect. This agent also stimulates dopamine D2 receptors in the anterior pituitary gland, which results in the inhibition of prolactin secretion and lactation and may inhibit the proliferation of prolactin-dependent breast cancer cells." @default.
- NCIT_C317 NCIT_A32 NCIT_C1909 @default.
- NCIT_C317 NCIT_A6 NCIT_C62010 @default.
- NCIT_C317 NCIT_NHC0 "C317" @default.
- NCIT_C317 NCIT_P106 "Organic Chemical" @default.
- NCIT_C317 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C317 NCIT_P108 "Bromocriptine Mesylate" @default.
- NCIT_C317 NCIT_P207 "C0546852" @default.
- NCIT_C317 NCIT_P210 "22260-51-1" @default.
- NCIT_C317 NCIT_P302 "the treatment of dysfunctions associated with hyperprolactinemia including amenorrhea with or without galactorrhea, infertility or hypogonadism. Parlodel treatment is indicated in patients with prolactin-secreting adenomas." @default.
- NCIT_C317 NCIT_P319 "FFP983J3OD" @default.
- NCIT_C317 NCIT_P322 "FDA" @default.
- NCIT_C317 NCIT_P322 "GDC" @default.
- NCIT_C317 NCIT_P329 "39165" @default.
- NCIT_C317 NCIT_P330 "39165" @default.
- NCIT_C317 NCIT_P350 "C32H40BrN5O5.CH4O3S" @default.
- NCIT_C317 NCIT_P366 "Bromocriptine" @default.
- NCIT_C317 NCIT_P368 "CHEBI:3182" @default.
- NCIT_C317 NCIT_P375 "Bromocriptine Mesylate" @default.
- NCIT_C317 NCIT_P399 "39165" @default.
- NCIT_C317 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C317 referenceCount "3" @default.
- NCIT_C317 hasExactSynonym "2-Bromo-alpha-ergocryptine Mesylate" @default.
- NCIT_C317 hasExactSynonym "BROMOCRIPTINE MESYLATE" @default.
- NCIT_C317 hasExactSynonym "Bromocriptine Mesylate" @default.
- NCIT_C317 hasExactSynonym "Ergotaman-3',6',18-trione, 2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, monomethanesulfonate (salt), (5'alpha)-" @default.
- NCIT_C317 hasExactSynonym "Parlodel" @default.
- NCIT_C317 inSubset NCIT_C128784 @default.
- NCIT_C317 inSubset NCIT_C157711 @default.
- NCIT_C317 inSubset NCIT_C157712 @default.
- NCIT_C317 inSubset NCIT_C176424 @default.
- NCIT_C317 inSubset NCIT_C177537 @default.
- NCIT_C317 inSubset NCIT_C63923 @default.
- NCIT_C317 type Class @default.
- NCIT_C317 isDefinedBy ncit.owl @default.
- NCIT_C317 label "Bromocriptine Mesylate" @default.
- NCIT_C317 subClassOf NCIT_C1509 @default.
- NCIT_C317 subClassOf NCIT_C1908 @default.
- NCIT_C317 subClassOf NCIT_C1909 @default.
- NCIT_C317 subClassOf NCIT_C26170 @default.
- NCIT_C317 subClassOf NCIT_C317 @default.
- NCIT_C317 subClassOf NCIT_C66884 @default.
- NCIT_C317 subClassOf NCIT_C78272 @default.