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- NCIT_C33976 IAO_0000115 "Neurogenic locus notch homolog protein 1 (2555 aa, ~273 kDa) is encoded by the human NOTCH1 gene. This protein is involved in both cell-cell signaling and cell-fate determination." @default.
- NCIT_C33976 NCIT_NHC0 "C33976" @default.
- NCIT_C33976 NCIT_P100 "190198" @default.
- NCIT_C33976 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C33976 NCIT_P106 "Receptor" @default.
- NCIT_C33976 NCIT_P107 "Neurogenic Locus Notch Homolog Protein 1" @default.
- NCIT_C33976 NCIT_P108 "Neurogenic Locus Notch Homolog Protein 1" @default.
- NCIT_C33976 NCIT_P207 "C1335068" @default.
- NCIT_C33976 NCIT_P322 "CTRP" @default.
- NCIT_C33976 NCIT_P366 "Notch_Homolog-1_Protein" @default.
- NCIT_C33976 NCIT_P93 "P46531" @default.
- NCIT_C33976 NCIT_P98 "Neurogenic locus notch homolog protein 1 contains 36 extracellular EGF domains, 3 Lin/Notch repeats, and multiple intracellular domains, including 5 ANK repeats. Cleaved by a Golgi furin-like convertase, cell surface Notch protein is a disulfide linked N-/C-terminal heterodimeric receptor for membrane-bound Jagged1, Jagged2, Delta1, and Serrate on adjacent cells that activates an conserved intercellular signaling pathway (lateral inhibition) to regulate cell-fate determination, differentiation, proliferation, and apoptotic programs. Activated Notch cleavage by TACE and presenilin dependent gamma-secretase releases the intracellular domain to form a transcription complex with RBP-J kappa to activate enhancer of split genes. NOTCH1 interacts with DTX1 and DTX2 and may regulate thymic lymphocyte maturation." @default.
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- NCIT_C33976 normalizedInformationContent "82.080392758357064" @default.
- NCIT_C33976 referenceCount "15" @default.
- NCIT_C33976 hasExactSynonym "NOTCH1" @default.
- NCIT_C33976 hasExactSynonym "Neurogenic Locus Notch Homolog Protein 1" @default.
- NCIT_C33976 hasExactSynonym "Notch Homolog 1" @default.
- NCIT_C33976 hasExactSynonym "Notch1 Preproprotein" @default.
- NCIT_C33976 hasExactSynonym "TAN-1" @default.
- NCIT_C33976 hasExactSynonym "TAN1" @default.
- NCIT_C33976 hasExactSynonym "Translocation-Associated Notch Protein TAN-1" @default.
- NCIT_C33976 hasExactSynonym "hN1" @default.
- NCIT_C33976 inSubset NCIT_C116977 @default.
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- NCIT_C33976 type Class @default.
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- NCIT_C33976 label "Neurogenic Locus Notch Homolog Protein 1" @default.
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