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- NCIT_C340 IAO_0000115 "A sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity. Captopril competitively inhibits angiotensin converting enzyme (ACE), thereby decreasing levels of angiotensin II, increasing plasma renin activity, and decreasing aldosterone secretion. This agent may also inhibit tumor angiogenesis by inhibiting endothelial cell matrix metalloproteinases (MMPs) and endothelial cell migration. Captopril may also exhibit antineoplastic activity independent of effects on tumor angiogenesis. (NCI04)" @default.
- NCIT_C340 NCIT_A32 NCIT_C1909 @default.
- NCIT_C340 NCIT_NHC0 "C340" @default.
- NCIT_C340 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C340 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C340 NCIT_P108 "Captopril" @default.
- NCIT_C340 NCIT_P175 "719847" @default.
- NCIT_C340 NCIT_P207 "C0006938" @default.
- NCIT_C340 NCIT_P210 "62571-86-2" @default.
- NCIT_C340 NCIT_P302 "Hypertension; Heart failure; Left ventricular dysfunction; Diabetic nephropathy" @default.
- NCIT_C340 NCIT_P319 "9G64RSX1XD" @default.
- NCIT_C340 NCIT_P322 "FDA" @default.
- NCIT_C340 NCIT_P322 "GDC" @default.
- NCIT_C340 NCIT_P325 "A drug used to treat high blood pressure that is also being studied in the prevention of side effects caused by radiation therapy used in the treatment of cancer. It belongs to the family of drugs called ACE inhibitors." @default.
- NCIT_C340 NCIT_P329 "37824" @default.
- NCIT_C340 NCIT_P330 "37824" @default.
- NCIT_C340 NCIT_P350 "C9H15NO3S" @default.
- NCIT_C340 NCIT_P366 "Captopril" @default.
- NCIT_C340 NCIT_P368 "CHEBI:3380" @default.
- NCIT_C340 NCIT_P375 "Captopril" @default.
- NCIT_C340 NCIT_P399 "37824" @default.
- NCIT_C340 NCIT_R122 NCIT_C16484 @default.
- NCIT_C340 NCIT_R122 NCIT_C16486 @default.
- NCIT_C340 NCIT_R122 NCIT_C16554 @default.
- NCIT_C340 NCIT_R122 NCIT_C16865 @default.
- NCIT_C340 NCIT_R122 NCIT_C16946 @default.
- NCIT_C340 NCIT_R122 NCIT_C17021 @default.
- NCIT_C340 NCIT_R122 NCIT_C17287 @default.
- NCIT_C340 NCIT_R122 NCIT_C20027 @default.
- NCIT_C340 NCIT_R122 NCIT_C26548 @default.
- NCIT_C340 NCIT_R122 NCIT_C28459 @default.
- NCIT_C340 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C340 referenceCount "2" @default.
- NCIT_C340 hasExactSynonym "(S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline" @default.
- NCIT_C340 hasExactSynonym "CAPTOPRIL" @default.
- NCIT_C340 hasExactSynonym "Capoten" @default.
- NCIT_C340 hasExactSynonym "Captopril" @default.
- NCIT_C340 hasExactSynonym "captopril" @default.
- NCIT_C340 inSubset NCIT_C128784 @default.
- NCIT_C340 inSubset NCIT_C157711 @default.
- NCIT_C340 inSubset NCIT_C157712 @default.
- NCIT_C340 inSubset NCIT_C173381 @default.
- NCIT_C340 inSubset NCIT_C173383 @default.
- NCIT_C340 inSubset NCIT_C176424 @default.
- NCIT_C340 inSubset NCIT_C177537 @default.
- NCIT_C340 inSubset NCIT_C63923 @default.
- NCIT_C340 type Class @default.
- NCIT_C340 isDefinedBy ncit.owl @default.
- NCIT_C340 label "Captopril" @default.
- NCIT_C340 subClassOf B05bd53f26757c58f26924d47e44174e8 @default.
- NCIT_C340 subClassOf B5144f3bb81e727da25e8bd55dae79ff9 @default.
- NCIT_C340 subClassOf NCIT_C1908 @default.
- NCIT_C340 subClassOf NCIT_C1909 @default.
- NCIT_C340 subClassOf NCIT_C247 @default.
- NCIT_C340 subClassOf NCIT_C270 @default.
- NCIT_C340 subClassOf NCIT_C340 @default.
- NCIT_C340 subClassOf NCIT_C471 @default.
- NCIT_C340 subClassOf NCIT_C78274 @default.
- NCIT_C340 subClassOf NCIT_C783 @default.