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- NCIT_C355 IAO_0000115 "The sodium salt of ceftazidime, a third-generation cephalosporin antibiotic with bactericidal activity. Ceftazidime binds to and inactivates penicillin-binding proteins (PBPs), enzymes located on the inner membrane of the bacterial cell wall, resulting in the weakening of the bacterial cell wall and cell lysis. Compared to the second and first generation cephalosporins, ceftazidime is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftazidine also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS). PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity." @default.
- NCIT_C355 NCIT_A6 NCIT_C66868 @default.
- NCIT_C355 NCIT_NHC0 "C355" @default.
- NCIT_C355 NCIT_P106 "Antibiotic" @default.
- NCIT_C355 NCIT_P106 "Organic Chemical" @default.
- NCIT_C355 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C355 NCIT_P108 "Ceftazidime Sodium" @default.
- NCIT_C355 NCIT_P207 "C0700860" @default.
- NCIT_C355 NCIT_P210 "78439-06-2" @default.
- NCIT_C355 NCIT_P319 "CMC30V039K" @default.
- NCIT_C355 NCIT_P322 "FDA" @default.
- NCIT_C355 NCIT_P329 "39179" @default.
- NCIT_C355 NCIT_P330 "39179" @default.
- NCIT_C355 NCIT_P350 "C22H21N6O7S2.Na" @default.
- NCIT_C355 NCIT_P366 "Ceftazidime" @default.
- NCIT_C355 NCIT_P399 "39179" @default.
- NCIT_C355 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C355 referenceCount "2" @default.
- NCIT_C355 hasExactSynonym "CEFTAZIDIME SODIUM" @default.
- NCIT_C355 hasExactSynonym "Ceftazidime Sodium" @default.
- NCIT_C355 hasExactSynonym "Tazicef" @default.
- NCIT_C355 inSubset NCIT_C176424 @default.
- NCIT_C355 inSubset NCIT_C63923 @default.
- NCIT_C355 type Class @default.
- NCIT_C355 isDefinedBy ncit.owl @default.
- NCIT_C355 label "Ceftazidime Sodium" @default.
- NCIT_C355 subClassOf NCIT_C1908 @default.
- NCIT_C355 subClassOf NCIT_C1909 @default.
- NCIT_C355 subClassOf NCIT_C254 @default.
- NCIT_C355 subClassOf NCIT_C258 @default.
- NCIT_C355 subClassOf NCIT_C260 @default.
- NCIT_C355 subClassOf NCIT_C355 @default.
- NCIT_C355 subClassOf NCIT_C357 @default.