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- NCIT_C368 IAO_0000115 "Secreted by Vibrio cholerae, Cholera Toxin is a natural bacterial enterotoxin consisting of major components heavy A- and light B peptides (choleragenoid) that initiates a signaling cascade in intestinal epithelial cells causing a dysfunction of chloride channels, loss of water, and diarrhea. B peptide anchors the protein to epithelia; A peptide enters the cytoplasm and activates adenylate cyclase. Due to its cytotoxicity, cholera toxin is being studied for tumor cell targeting and cancer chemotherapy. (NCI04)" @default.
- NCIT_C368 NCIT_NHC0 "C368" @default.
- NCIT_C368 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C368 NCIT_P106 "Hazardous or Poisonous Substance" @default.
- NCIT_C368 NCIT_P108 "Cholera Toxin" @default.
- NCIT_C368 NCIT_P207 "C0008356" @default.
- NCIT_C368 NCIT_P210 "9012-63-9" @default.
- NCIT_C368 NCIT_P366 "Cholera_Toxin" @default.
- NCIT_C368 normalizedInformationContent "100" @default.
- NCIT_C368 referenceCount "1" @default.
- NCIT_C368 hasExactSynonym "Cholera Toxin" @default.
- NCIT_C368 type Class @default.
- NCIT_C368 isDefinedBy ncit.owl @default.
- NCIT_C368 label "Cholera Toxin" @default.
- NCIT_C368 subClassOf NCIT_C1908 @default.
- NCIT_C368 subClassOf NCIT_C1932 @default.
- NCIT_C368 subClassOf NCIT_C296 @default.
- NCIT_C368 subClassOf NCIT_C368 @default.
- NCIT_C368 subClassOf NCIT_C470 @default.
- NCIT_C368 subClassOf NCIT_C894 @default.