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- NCIT_C37899 IAO_0000115 "A benzoquinone antineoplastic antibiotic derived from the antineoplastic antibiotic geldanamycin. Tanespimycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be overexpressed by tumor cells." @default.
- NCIT_C37899 NCIT_A32 NCIT_C1909 @default.
- NCIT_C37899 NCIT_A7 NCIT_C17766 @default.
- NCIT_C37899 NCIT_NHC0 "C37899" @default.
- NCIT_C37899 NCIT_P106 "Antibiotic" @default.
- NCIT_C37899 NCIT_P106 "Organic Chemical" @default.
- NCIT_C37899 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C37899 NCIT_P107 "Tanespimycin" @default.
- NCIT_C37899 NCIT_P108 "Tanespimycin" @default.
- NCIT_C37899 NCIT_P175 "330507" @default.
- NCIT_C37899 NCIT_P207 "C0675974" @default.
- NCIT_C37899 NCIT_P210 "75747-14-7" @default.
- NCIT_C37899 NCIT_P302 "Chronic Myelogenous Leukemia" @default.
- NCIT_C37899 NCIT_P319 "4GY0AVT3L4" @default.
- NCIT_C37899 NCIT_P322 "CTRP" @default.
- NCIT_C37899 NCIT_P322 "FDA" @default.
- NCIT_C37899 NCIT_P322 "GDC" @default.
- NCIT_C37899 NCIT_P325 "A substance being studied in the treatment of cancer. It is made from an antibiotic called geldanamycin. Tanespimycin helps cause the breakdown of certain proteins in the cell, and may kill cancer cells. It is a type of antineoplastic antibiotic and a type of HSP90 inhibitor." @default.
- NCIT_C37899 NCIT_P329 "43635" @default.
- NCIT_C37899 NCIT_P330 "43635" @default.
- NCIT_C37899 NCIT_P350 "C31H43N3O8" @default.
- NCIT_C37899 NCIT_P366 "_17-Allylamino_17-demethoxygeldanamycin" @default.
- NCIT_C37899 NCIT_P368 "CHEBI:64153" @default.
- NCIT_C37899 NCIT_P375 "Tanespimycin" @default.
- NCIT_C37899 NCIT_P399 "43635" @default.
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- NCIT_C37899 NCIT_R146 NCIT_C16672 @default.
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- NCIT_C37899 NCIT_R146 NCIT_C20130 @default.
- NCIT_C37899 NCIT_R146 NCIT_C26548 @default.
- NCIT_C37899 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C37899 referenceCount "2" @default.
- NCIT_C37899 hasExactSynonym "17-(Allylamino)-17-demethoxygeldanamycin" @default.
- NCIT_C37899 hasExactSynonym "17-AAG" @default.
- NCIT_C37899 hasExactSynonym "17-Allylamino-17-demethoxygeldanamycin" @default.
- NCIT_C37899 hasExactSynonym "17-Demethoxy-17-(2-propenylamino)geldanamycin" @default.
- NCIT_C37899 hasExactSynonym "17-N-allylamino-17-demethoxy geldanamycin" @default.
- NCIT_C37899 hasExactSynonym "17-N-allylamino-17-demethoxygeldanamycin" @default.
- NCIT_C37899 hasExactSynonym "Geldanamycin, 17-allylamino-17-demethoxy-" @default.
- NCIT_C37899 hasExactSynonym "KOS-953" @default.
- NCIT_C37899 hasExactSynonym "TANESPIMYCIN" @default.
- NCIT_C37899 hasExactSynonym "Tanespimycin" @default.
- NCIT_C37899 hasExactSynonym "tanespimycin" @default.
- NCIT_C37899 inSubset NCIT_C116977 @default.
- NCIT_C37899 inSubset NCIT_C116978 @default.
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- NCIT_C37899 inSubset NCIT_C63923 @default.
- NCIT_C37899 type Class @default.
- NCIT_C37899 isDefinedBy ncit.owl @default.
- NCIT_C37899 label "Tanespimycin" @default.
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