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- NCIT_C380 IAO_0000115 "An imidazoline derivate and centrally-acting alpha-adrenergic agonist, with antihypertensive activity. Clonidine binds to and stimulates central alpha-2 adrenergic receptors, thereby reducing the amount of norepinephrine (NE) release and thus decreasing sympathetic outflow to the heart, kidneys, and peripheral vasculature. The reduction in sympathetic outflow leads to decreased peripheral vascular resistance, decreased blood pressure, and decreased heart rate. In addition, clonidine binds to imidazoline receptor subtype 1 (I1), which may also contribute to a reduction in blood pressure." @default.
- NCIT_C380 NCIT_A5 NCIT_C47979 @default.
- NCIT_C380 NCIT_NHC0 "C380" @default.
- NCIT_C380 NCIT_P106 "Organic Chemical" @default.
- NCIT_C380 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C380 NCIT_P108 "Clonidine" @default.
- NCIT_C380 NCIT_P207 "C0009014" @default.
- NCIT_C380 NCIT_P210 "4205-90-7" @default.
- NCIT_C380 NCIT_P319 "MN3L5RMN02" @default.
- NCIT_C380 NCIT_P322 "FDA" @default.
- NCIT_C380 NCIT_P325 "The active ingredient in a drug used to treat high blood pressure. It is also being studied in the treatment of certain types of cancer pain. It blocks the release of chemicals from nerve endings that make blood vessels constrict (get narrower). Clonidine is a type of antihypertensive agent and a type of alpha-adrenergic agonist." @default.
- NCIT_C380 NCIT_P329 "41228" @default.
- NCIT_C380 NCIT_P330 "41228" @default.
- NCIT_C380 NCIT_P350 "C9H9Cl2N3" @default.
- NCIT_C380 NCIT_P366 "Clonidine" @default.
- NCIT_C380 NCIT_P368 "CHEBI:3757" @default.
- NCIT_C380 NCIT_P368 "CHEBI:46631" @default.
- NCIT_C380 NCIT_P368 "CHEBI:46632" @default.
- NCIT_C380 NCIT_P399 "41228" @default.
- NCIT_C380 normalizedInformationContent "100" @default.
- NCIT_C380 referenceCount "1" @default.
- NCIT_C380 hasExactSynonym "CLONIDINE" @default.
- NCIT_C380 hasExactSynonym "Catapres-TTS" @default.
- NCIT_C380 hasExactSynonym "Clonidine" @default.
- NCIT_C380 hasExactSynonym "N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine" @default.
- NCIT_C380 hasExactSynonym "clonidine" @default.
- NCIT_C380 inSubset NCIT_C176424 @default.
- NCIT_C380 inSubset NCIT_C63923 @default.
- NCIT_C380 type Class @default.
- NCIT_C380 isDefinedBy ncit.owl @default.
- NCIT_C380 label "Clonidine" @default.
- NCIT_C380 subClassOf NCIT_C1908 @default.
- NCIT_C380 subClassOf NCIT_C1909 @default.
- NCIT_C380 subClassOf NCIT_C29709 @default.
- NCIT_C380 subClassOf NCIT_C29747 @default.
- NCIT_C380 subClassOf NCIT_C380 @default.
- NCIT_C380 subClassOf NCIT_C78272 @default.
- NCIT_C380 subClassOf NCIT_C87053 @default.